Evidence map›Paper›PMID 38562743›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Microbial determinants of dementia risk in subjects of Mexican descent with type 2 diabetes living in South Texas.

Lisa M Matz, Nisarg S Shah, Laura Porterfield, Olivia M Stuyck, Michael D Jochum, Rakez Kayed, Giulio Taglialatela, Randall J Urban, Shelly A Buffington

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Lisa M MatzCenter for Precision Environmental Health, Baylor College of Medicine, Houston, TX, USA.
Nisarg S ShahDepartment of Internal Medicine, The University of Texas Medical Branch at Galveston, Galveston, TX, USA.
Laura PorterfieldDepartment of Family Medicine, The University of Texas Medical Branch at Galveston, Galveston, TX, USA.
Olivia M StuyckDepartment of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, USA.
Michael D JochumDepartment of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, USA.
Rakez KayedDepartment of Neurology, Mitchell Center for Neurodegenerative Diseases, The University of Texas Medical Branch at Galveston, Galveston, TX, USA.
Giulio TaglialatelaDepartment of Neurology, Mitchell Center for Neurodegenerative Diseases, The University of Texas Medical Branch at Galveston, Galveston, TX, USA.
Randall J UrbanDepartment of Internal Medicine, The University of Texas Medical Branch at Galveston, Galveston, TX, USA.
Shelly A BuffingtonCenter for Precision Environmental Health, Baylor College of Medicine, Houston, TX, USA.
The University of Texas Medical Branch at Galveston · USBaylor College of Medicine · US

Funding

Predoctoral and Postdoctoral Training in Alzheimer's PathophysiologyT32AG067952 · NIA · UNIVERSITY OF TEXAS MED BR GALVESTON · 2021 to 2025
$458k
NCATS NIH HHS UL1 TR001439NIA NIH HHS T32 AG067952
6 · The paper itself

Abstract

Type 2 diabetes (T2D) is a common forerunner of neurodegeneration and dementia, including Alzheimer's Disease (AD), yet the underlying mechanisms remain unresolved. Individuals of Mexican descent living in South Texas have increased prevalence of comorbid T2D and early onset AD, despite low incidence of the predisposing APOE-e4 variant and an absence of the phenotype among relatives residing in Mexico - suggesting a role for environmental factors in coincident T2D and AD susceptibility. Here, in a small clinical trial, we show dysbiosis of the human gut microbiome could contribute to neuroinflammation and risk for AD in this population. Divergent Gastrointestinal Symptom Rating Scale (GSRS) responses, despite no differences in expressed dietary preferences, provided the first evidence for altered gut microbial ecology among T2D subjects (sT2D)

Indexed as

Alzheimer’s DiseaseComorbidityGut MicrobiotaMetabolic DisordersMexican AmericanNeurodegenerationPathobiontsShort-Chain Fatty AcidsType 2 DiabetesWestern Diet

Identifiers

PMID38562743
PMCPMC10984044
OpenAlexW4393065782

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.