Evidence map›Paper›PMID 38562765›Full record

ArticlebioRxiv : the preprint server for biology2024

VLK drives extracellular phosphorylation of EphB2 to govern the EphB2-NMDAR interaction and injury-induced pain.

Kolluru D Srikanth, Hajira Elahi, Praveen Chander, Halley R Washburn, Shayne Hassler, Juliet M Mwirigi, Moeno Kume, Jessica Loucks, Rohita Arjarapu, Rachel Hodge and 8 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 2 countries.

Kolluru D SrikanthTulane Brain Institute, Department of Cell and Molecular Biology, Tulane University; New Orleans, LA 70118, USA.
Hajira ElahiDepartment of Neuroscience, The University of Texas at Dallas; Richardson, TX 75080, USA.
Praveen ChanderTulane Brain Institute, Department of Cell and Molecular Biology, Tulane University; New Orleans, LA 70118, USA.
Halley R WashburnJefferson Synaptic Biology Center, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA 19107.
Shayne HasslerDepartment of Neuroscience, The University of Texas at Dallas; Richardson, TX 75080, USA.
Juliet M MwirigiDepartment of Neuroscience, The University of Texas at Dallas; Richardson, TX 75080, USA.
Moeno KumeDepartment of Neuroscience, The University of Texas at Dallas; Richardson, TX 75080, USA.
Jessica LoucksDepartment of Neuroscience, The University of Texas at Dallas; Richardson, TX 75080, USA.
Rohita ArjarapuDepartment of Neuroscience, The University of Texas at Dallas; Richardson, TX 75080, USA.
Rachel HodgeJefferson Synaptic Biology Center, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA 19107.
Stephanie I ShiersDepartment of Neuroscience, The University of Texas at Dallas; Richardson, TX 75080, USA.
Ishwarya SankaranarayananDepartment of Neuroscience, The University of Texas at Dallas; Richardson, TX 75080, USA.
Hediye Erdjument-BromageDepartment of Neuroscience and Physiology and Neuroscience Institute, NYU Grossman School of Medicine, New York, NY, 10016, USA.
Thomas A NeubertDepartment of Neuroscience and Physiology and Neuroscience Institute, NYU Grossman School of Medicine, New York, NY, 10016, USA.
Zachary T CampbellDepartment of Anesthesiology, University of Wisconsin-Madison; Madison, WI 53792, USA.
Raehum PaikDepartment of Anesthesiology, University of Wisconsin-Madison; Madison, WI 53792, USA.
Theodore J PriceDepartment of Neuroscience, The University of Texas at Dallas; Richardson, TX 75080, USA.ORCID 0000-0002-6971-6221
Matthew B DalvaTulane Brain Institute, Department of Cell and Molecular Biology, Tulane University; New Orleans, LA 70118, USA.
The University of Texas at Dallas · USTulane University · USNeurosciences Institute · USThomas Jefferson University · USUniversity of Wisconsin–Madison · US

Funding

Exploring the EphB2-NMDA receptor interaction in spinal cord injury-induced neuropathic painR01NS110385 · NINDS · THOMAS JEFFERSON UNIVERSITY · PI MANUEL L COVARRUBIAS, Matthew B Dalva · 2018 to 2026
$4.4M
Profiling Translation in Nociceptor PlasticityR01NS114018 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI Zachary Campbell · 2020 to 2026
$3.2M
Extracellular mechanism regulating synaptic function and pain plasticityR01NS111976 · NINDS · THOMAS JEFFERSON UNIVERSITY · PI DALVA, MATTHEW B, PRICE, THEODORE J. · 2019 to 2023
$2.6M
Novel mechanisms regulating protein interaction and painR01NS115441 · NINDS · THOMAS JEFFERSON UNIVERSITY · PI DALVA, MATTHEW B, PRICE, THEODORE J. · 2020 to 2023
$2.1M
LTQ-Orbitrap Mass Spectrometer.S10RR027990 · NCRR · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI NEUBERT, THOMAS A · 2011 to 2011
$600k
NCRR NIH HHS S10 RR027990NINDS NIH HHS R01 NS110385NINDS NIH HHS R01 NS111976NINDS NIH HHS R01 NS114018NINDS NIH HHS R01 NS115441
6 · The paper itself

Abstract

Phosphorylation of hundreds of protein extracellular domains is mediated by two kinase families, yet the significance of these kinases is underexplored. Here, we find that the presynaptic release of the tyrosine directed-ectokinase, Vertebrate Lonesome Kinase (VLK/Pkdcc), is necessary and sufficient for the direct extracellular interaction between EphB2 and GluN1 at synapses, for phosphorylation of the ectodomain of EphB2, and for injury-induced pain.

Identifiers

PMID38562765
PMCPMC10983893
OpenAlexW4393095181

What Socratic holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.