Evidence map›Paper›PMID 38562891›Full record

ArticlebioRxiv : the preprint server for biology2024

Incretin hormones and pharmacomimetics rapidly inhibit AgRP neuron activity to suppress appetite.

Hayley E McMorrow, Carolyn M Lorch, Nikolas W Hayes, Stefan W Fleps, Joshua A Frydman, Jessica L Xia, Ricardo J Samms, Lisa R Beutler

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 10 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Hayley E McMorrowDepartment of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University, Chicago, IL 60611, USA.
Carolyn M LorchDepartment of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University, Chicago, IL 60611, USA.
Nikolas W HayesDepartment of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University, Chicago, IL 60611, USA.
Stefan W FlepsDepartment of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University, Chicago, IL 60611, USA.
Joshua A FrydmanDepartment of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University, Chicago, IL 60611, USA.
Jessica L XiaDepartment of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University, Chicago, IL 60611, USA.
Ricardo J SammsDiabetes, Obesity and Complications Therapeutic Area, Eli Lilly, Indianapolis, IN, USA.
Lisa R BeutlerDepartment of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0002-9489-8098
Northwestern University · USEli Lilly (United States) · US

Funding

Pilot and Feasibility ProgramP30DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI Matthew J Brady · 2013 to 2026
$20.9M
Rapid hormonal modulation of feeding circuit dynamics and its disruption in obesityR01DK128477 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BEUTLER, LISA R · 2021 to 2025
$1.9M
Dissecting the Nutritional Regulation of Feeding CircuitsK08DK118188 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BEUTLER, LISA R · 2018 to 2021
$690k
NIDDK NIH HHS K08 DK118188NIDDK NIH HHS P30 DK020595NIDDK NIH HHS R01 DK128477
6 · The paper itself

Abstract

Analogs of the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) have become mainstays of obesity and diabetes management. However, both the physiologic role of incretin hormones in the control of appetite and the pharmacologic mechanisms by which incretin-mimetic drugs suppress caloric intake remain incompletely understood. Hunger-promoting AgRP-expressing neurons are an important hypothalamic population that regulates food intake. Therefore, we set out to determine how incretins analogs affect their activity

Identifiers

PMID38562891
PMCPMC10983981
OpenAlexW4392978764

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.