Evidence map›Paper›PMID 38564675›Full record

ArticlemBio2024

Metagenome diversity illuminates the origins of pathogen effectors.

Stephanie S Lehman, Victoria I Verhoeve, Timothy P Driscoll, John F Beckmann, Joseph J Gillespie

Open access · goldAbstract read
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
5.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Facultative mutualism betweenISME communications · 2026
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  6. TlyC, a conserved hemolysin inMicrobiology spectrum · 2025
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  7. Article
  8. Rickettsioses Seropositivity in Malaysia: A Six-Year Trend, 2016-2021.Tropical medicine and infectious disease · 2025
    Article
  9. Article
  10. Article
  11. Genomic analysis of co-infection withFrontiers in microbiology · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. bioRxiv : the preprint server for biology · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Stephanie S LehmanDivision of Molecular and Cellular Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
Victoria I VerhoeveDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Timothy P DriscollDepartment of Biology, West Virginia University, Morgantown, West Virginia, USA.
John F BeckmannDepartment of Microbiology and Immunology, University of South Alabama, Mobile, Alabama, USA.
Joseph J GillespieDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-5447-7264
University of Maryland, Baltimore · USNational Institutes of Health · USUniversity of South Alabama · USWest Virginia University · US

Funding

Characterizing the Pan-genome of a Rickettsia Infecting the Eastern Black-legged TickR21AI156762 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI DRISCOLL, TIMOTHY P, GILLESPIE, JOSEPH J · 2021 to 2022
$435k
Investigating Rickettsia Interspecies and Host-Specific Lipopolysaccharide VariationR21AI166832 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI GILLESPIE, JOSEPH J · 2022 to 2023
$425k
NIAID NIH HHS R21 AI156762NIAID NIH HHS R21 AI166832
6 · The paper itself

Abstract

Recent metagenome-assembled genome (MAG) analyses have profoundly impacted Rickettsiology systematics. The discovery of basal lineages (novel families Mitibacteraceae and Athabascaceae) with predicted extracellular lifestyles exposed an evolutionary timepoint for the transition to host dependency, which seemingly occurred independent of mitochondrial evolution. Notably, these basal rickettsiae carry the Rickettsiales

Indexed as

Genome, BacterialMetagenomePhylogenyRickettsiaBacterial ProteinsEvolution, MolecularGenetic VariationGene Transfer, HorizontalHumansRickettsialesType IV Secretion SystemsBacterial ProteinsType IV Secretion SystemseffectorevolutionmetagenomeRickettsiatype IV secretion system

Identifiers

PMID38564675
PMCPMC11077975
OpenAlexW4393570320

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.