ArticleeLife2024
Vitamin D constrains inflammation by modulating the expression of key genes on Chr17q12-21.1.
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Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14citing papers in PubMed
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Who cites it
14 citing papers in PubMed, 8 citations in OpenAlex.
- Natural Products Targeting Airway Inflammation and Mucus Hypersecretion: Molecular Mechanisms and Therapeutic Potential for Respiratory Health.Nutrients · 2026Review
- Heparanase, Endothelial Dysfunction, and Cardiovascular Risk: The Emerging Role of Vitamin D.ACS pharmacology & translational science · 2026Review
- Vitamin D receptor signaling in inflammatory senescence-associated skin aging: Mechanisms and therapeutic potentials.Journal of cell communication and signaling · 2026Article
- Tfcp2l1 participates in paternal vitamin D deficiency-induced fetal lung maldevelopment in mice.Genes & nutrition · 2026Article
- Microbiome, Epigenetics, and Nutritional Factors in Shaping Perinatal Pregnancy Outcomes.International journal of molecular sciences · 2026Review
- Hemoglobin-to-Red cell distribution width ratio and asthma risk: cross-population validation and vitamin D mediation analysis.Frontiers in allergy · 2026Article
- Holodiastolic Flow Reversal in the Descending Aorta: A Marker of Concomitant Acute Myocarditis and Aortitis in Children-A Case Series.Pediatric cardiology · 2026Article
- The therapeutic potential of vitamin D supplementation in asthma.Pharmacological reports : PR · 2025Review
- Vitamin D exerts endogenous control over TiScience · 2025Article
- Pharmacokinetic modeling of prenatal vitamin D exposure and the impact on offspring asthma and pulmonary function.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2025Article
- The Impact of Neutrophil-to-High-Density Lipoprotein Ratio and Serum 25-Hydroxyvitamin D on Ischemic Heart Disease.Journal of clinical medicine · 2024Article
- Investigating the role of vitamin D in asthma.eLife · 2024Article
- Association of Prenatal Maternal and Infant Vitamin D Supplementation with Offspring Asthma.Annals of the American Thoracic Society · 2024Article
- Vitamin D Receptor Gene Polymorphisms Differentiated Between Tuberculosis Disease and Infection: Causal Association Study.Infection and drug resistance · 2024Article
Corrections and comments
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Authors and funding
21 authors at 6 institutions in 4 countries.
Ayse Kilic *Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, United States.ORCID https://orcid.org/0000-0001-5362-2127
Arda Halu *Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, United States.ORCID https://orcid.org/0000-0001-6217-790X
Margherita De MarzioChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, United States.ORCID https://orcid.org/0000-0003-1821-208X
Enrico MaiorinoChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, United States.
Melody G DuvallDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, United States.ORCID https://orcid.org/0000-0002-4173-3628
Thayse Regina BruggemannDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, United States.
Joselyn J Rojas QuinteroDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, United States.
Robert ChaseChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, United States.
Hooman MirzakhaniChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, United States.
Ayse Özge SungurBehavioral Neuroscience, Experimental and Biological Psychology, Philipps-University, Marburg, Germany.ORCID https://orcid.org/0000-0002-9272-9717
Janine KoepkeExcellence Cluster Cardio-Pulmonary System (ECCPS), Justus Liebig University Giessen, Giessen, Germany.
Taiji NakanoDepartment of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan.
Hong Yong PehDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, United States.ORCID https://orcid.org/0000-0001-6098-9381
Nandini KrishnamoorthyDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, United States.
Raja-Elie AbdulnourDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, United States.
Katia GeorgopoulosCutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, United States.
Augusto A LitonjuaDivision of Pediatric Pulmonary Medicine, Golisano Children's Hospital at Strong, University of Rochester Medical Center, Rochester, United States.
Marie DemayEndocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, United States.
Harald RenzInstitute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Philipps University of Marburg and German Center for Lung Research (DZL), Marburg, Germany.
Bruce D LevyDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, United States.
Scott T Weiss *Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, United States.
Brigham and Women's Hospital · USHarvard University · USJustus-Liebig-Universität Gießen · DEChiba University · JPPhilipps University of Marburg · DEUniversity of Rochester Medical Center · US
Funding
VISUAL INDICES OF NEUROTOXICITYP30ES001247 · NIEHS · UNIVERSITY OF ROCHESTER · PI Martha Susiarjo · 1985 to 2026
$42.8MMulti-omic approaches to mechanisms of vitamin D, environmental influences, and the microbiome on asthmaUH3OD023268 · OD · BRIGHAM AND WOMEN'S HOSPITAL · PI LITONJUA, AUGUSTO A, WEISS, SCOTT T · 2018 to 2022
$13.5MSystems Biology of Airway DiseaseP01HL132825 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WEISS, SCOTT T · 2016 to 2020
$12.6MRANDOMIZED CONTROLLED TRIAL: VDAART CONTINUATION STUDY - DCC - LEADR01HL091528 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LITONJUA, AUGUSTO A, WEISS, SCOTT T · 2014 to 2018
$9.1MSpecialized Pro-Resolving Mediators in AsthmaR01HL122531 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LEVY, BRUCE D · 2014 to 2024
$4.7MUsing statistical network methods to elucidate the multi-omic modulators of the effect of maternal vitamin D levels on childhood asthmaR01HL171141 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Arda Halu · 2024 to 2026
$2.6MIntegrative network-based analysis of multi-omics data to elucidate the molecular connection between asthma and COPDK25HL150336 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI HALU, ARDA · 2020 to 2024
$945kIntegrative Longitudinal Genomics of Maternal Asthma-Preeclampsia Overlap and Risk of Childhood AsthmaK01HL146977 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MIRZAKHANI, HOOMAN · 2020 to 2024
$874kMechanogenomics of the asthmatic airway epitheliumK25HL168157 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Margherita De Marzio · 2023 to 2026
$753kLinking endotype and phenotype to understand COPD heterogeneity via deep learning and network scienceK01HL166705 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Enrico Maiorino · 2023 to 2026
$713kNHLBI NIH HHS 1K01HL166705NHLBI NIH HHS 1K25HL168157NHLBI NIH HHS 1R01HL171141NHLBI NIH HHS 5K25HL150336NHLBI NIH HHS 5P01HL132825NHLBI NIH HHS 5UH3OD023268NHLBI NIH HHS K01 HL146977NHLBI NIH HHS K01 HL166705NHLBI NIH HHS K25 HL150336NHLBI NIH HHS K25 HL168157NHLBI NIH HHS P01 HL132825NHLBI NIH HHS R01 HL091528NHLBI NIH HHS R01 HL122531NHLBI NIH HHS R01 HL171141NIEHS NIH HHS P30 ES001247NIH HHS UH3 OD023268
Abstract
Vitamin D possesses immunomodulatory functions and vitamin D deficiency has been associated with the rise in chronic inflammatory diseases, including asthma (Litonjua and Weiss, 2007). Vitamin D supplementation studies do not provide insight into the molecular genetic mechanisms of vitamin D-mediated immunoregulation. Here, we provide evidence for vitamin D regulation of two human chromosomal loci, Chr17q12-21.1 and Chr17q21.2, reliably associated with autoimmune and chronic inflammatory diseases. We demonstrate increased vitamin D receptor (
Indexed as
AsthmaPneumoniaVitamin D DeficiencyAnimalsHumansInflammationInterleukin-2MiceTh2 CellsVitamin DVitaminsInterleukin-2Vitamin DVitaminsasthmageneticsgenomicshumanimmunologyinflammationmousevitamin D receptor
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.