Evidence map›Paper›PMID 38568474›Full record

ArticleHeart and vessels2024

Clinical impact of cardiovascular calcifications on stroke incidence in primary prevention: analysis in NADESICO study.

Shinichi Wada, Yoshitaka Iwanaga, Michikazu Nakai, Yoshihiro Miyamoto, Teruo Noguchi

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Heart and vessels, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Shinichi WadaDepartment of Medical and Health Information Management, National Cerebral and Cardiovascular Center, 6-1 kishibe-shimmachi, Suita, Osaka, 564-8565, Japan.
Yoshitaka IwanagaDepartment of Medical and Health Information Management, National Cerebral and Cardiovascular Center, 6-1 kishibe-shimmachi, Suita, Osaka, 564-8565, Japan. yiwanaga@kuhp.kyoto-u.ac.jp.ORCID http://orcid.org/0000-0002-1391-2864
Michikazu NakaiDepartment of Medical and Health Information Management, National Cerebral and Cardiovascular Center, 6-1 kishibe-shimmachi, Suita, Osaka, 564-8565, Japan.
Yoshihiro MiyamotoDepartment of Medical and Health Information Management, National Cerebral and Cardiovascular Center, 6-1 kishibe-shimmachi, Suita, Osaka, 564-8565, Japan.
Teruo NoguchiDepartment of Cardiology, National Cerebral and Cardiovascular Center, Suita, Japan.
National Cerebral and Cardiovascular Center · JP

Funding

Japan Agency for Medical Research and Development 20gk0210026h001
6 · The paper itself

Abstract

The utility of assessment of cardiovascular calcifications for predicting stroke incidence remains unclear. This study assessed the relationship between cardiovascular calcifications including coronary artery calcification (CAC), aortic valve (AVC), and aortic root (ARC) assessed by coronary computed tomography (CT) and stroke incidence in patients with suspected CAD. In this multicenter prospective cohort study, 1187 patients suspected of CAD who underwent coronary CT were enrolled. Cardiovascular events including stroke were documented. Hazard ratio (HR) and confidence interval (CI) were assessed by Cox proportional hazard model adjusted for the Framingham risk score. C statistics for stroke incidence were also examined by models including cardiovascular calcifications. A total of 980 patients (mean age, 65 ± 7 years; females, 45.8%) were assessed by the CAC, AVC, and ARC Agatston scores. During a median follow-up of 4.0 years, 19 patients developed stroke. Cox proportional hazard model showed severe CAC (Agatston score ≥ 90th percentile [580.0 value]) and presence of AVC and ARC were associated with stroke incidence (HR; 10.33 [95% CI; 2.08-51.26], 3.08 [1.19-7.98], and 2.75 [1.03-7.30], respectively). C statistic in the model with CAC and AVC severity for predicting stroke incidence was 0.841 (95% CI; 0.761-0.920), which was superior to the model with CAC alone (0.762 [95% CI; 0.665-0.859], P < 0.01). CAC, AVC, and ARC were associated with stroke incidence in patients suspected of CAD. Assessment of both CAC and AVC may be useful for prediction of stroke incidence.

Indexed as

Coronary Artery DiseasePrimary PreventionStrokeVascular CalcificationAgedAortic ValveComputed Tomography AngiographyCoronary AngiographyFemaleFollow-Up StudiesHumansIncidenceMaleMiddle AgedProspective StudiesRisk AssessmentAortic root calcificationAortic valve calcificationCoronary artery calcificationCoronary artery diseaseStroke

Identifiers

PMID38568474
OpenAlexW4393870949

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.