Evidence map›Paper›PMID 38568964›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

WNK kinase is a vasoactive chloride sensor in endothelial cells.

Tessa A C Garrud, Briar Bell, Alejandro Mata-Daboin, Dieniffer Peixoto-Neves, Daniel M Collier, Julio F Cordero-Morales, Jonathan H Jaggar

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Hypotonicity-Induced WNK1 Phosphorylation Prevents HBasic & clinical pharmacology & toxicology · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Activation of WNK1 signaling through Piezo1.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Tessa A C GarrudDepartment of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163.ORCID 0000-0002-7900-7939
Briar BellDepartment of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163.ORCID 0000-0001-9797-6402
Alejandro Mata-DaboinDepartment of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163.ORCID 0000-0003-1831-7842
Dieniffer Peixoto-NevesDepartment of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163.ORCID 0000-0002-1190-5433
Daniel M CollierDepartment of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163.ORCID 0000-0001-9431-9271
Julio F Cordero-MoralesDepartment of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163.
Jonathan H JaggarDepartment of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163.ORCID 0000-0003-1505-3335
University of Tennessee Health Science Center · US

Funding

SK3 channel trafficking in endothelial cellsR01HL158846 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI JAGGAR, JONATHAN H · 2021 to 2024
$2.5M
Chloride channels in endothelial cellsR01HL166411 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI Jonathan H Jaggar · 2023 to 2026
$2.5M
PKD proteins in endothelial cellsR01HL155180 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI JAGGAR, JONATHAN H · 2021 to 2024
$2.4M
Sensory Ion Channel Modulation by Bioactive LipidsR35GM149218 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Julio Francisco Cordero-Morales · 2023 to 2026
$1.6M
American Heart Association-American Stroke Association 830462NHLBI NIH HHS R01 HL155180NHLBI NIH HHS R01 HL158846NHLBI NIH HHS R01 HL166411NIGMS NIH HHS R35 GM149218
6 · The paper itself

Abstract

Endothelial cells (ECs) line the wall of blood vessels and regulate arterial contractility to tune regional organ blood flow and systemic pressure. Chloride (Cl

Indexed as

ChloridesProtein Serine-Threonine KinasesAnimalsEndothelial CellsMiceSignal TransductionTRPV Cation ChannelsChloridesProtein Serine-Threonine KinasesTRPV Cation Channelsendothelial cellTMEM16ATRPV4vasodilationWNK kinase

Identifiers

PMID38568964
PMCPMC11009681
OpenAlexW4393853395

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.