ArticleScience translational medicine2024
Antibody-mediated targeting of human microglial leukocyte Ig-like receptor B4 attenuates amyloid pathology in a mouse model.
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Article in Science translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25citing papers in PubMed
7.9field-weighted citation impact, top 2% of its field
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Who cites it
25 citing papers in PubMed, 32 citations in OpenAlex.
- High-Throughput CETSA Identifies Small Molecule Modulators of ILT3 (LILRB4) with Functional Activity in Human iPSC-Derived Microglia for Alzheimer's Disease.ACS medicinal chemistry letters · 2026Article
- Adolescent intermittent ethanol exacerbates amyloid-β with age in the dorsal hippocampus of female TgF344-AD rats.Journal of Alzheimer's disease : JAD · 2026Article
- Microglial ITAM & ITIM Signaling in Neurodegenerative Disease and Brain Aging.Journal of molecular biology · 2026Review
- Claudins interact with LILRB immune inhibitory receptors to promote myeloid immunosuppression in cancer.Science immunology · 2026Article
- Analyses of plasma multi-omic data across ancestries identify novel pathways implicated in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Next-generation CAR-T therapy for acute myeloid leukemia: bridging innovation with clinical translation.Annals of hematology · 2026Review
- Hyperactivity of subicular parvalbumin interneurons drives early amyloid pathology and cognitive deficits in Alzheimer's disease.Molecular psychiatry · 2025Article
- Adolescent intermittent ethanol exacerbates Aβ with age in the dorsal hippocampus of female TgF344-AD rats.bioRxiv : the preprint server for biology · 2025Article
- Secretogranin 2 binds LILRB4 resulting in immunosuppression.Nature immunology · 2025Article
- Causal disentanglement for single-cell representations and controllable counterfactual generation.Nature communications · 2025Article
- Biomarkers and therapeutic strategies targeting microglia in neurodegenerative diseases: current status and future directions.Molecular neurodegeneration · 2025Review
- Uncovering the Associations of LILRB4 Genotypes With Parkinson's Disease: From Clinical Traits to Potential Pathologies.CNS neuroscience & therapeutics · 2025Article
- Unraveling the complex role of microglia in Alzheimer's disease: amyloid β metabolism and plaque formation.Inflammation and regeneration · 2025Review
- Human longevity and Alzheimer's disease variants act via microglia and oligodendrocyte gene networks.Brain : a journal of neurology · 2025Article
- Transcriptomic and Histological Characterization of Telocytes in the Human Dorsal Root Ganglion.The Journal of comparative neurology · 2025Article
- The role of inhibitory immune checkpoint receptors in the pathogenesis of Alzheimer's disease.Journal of molecular medicine (Berlin, Germany) · 2025Review
- Inhibitory leukocyte immunoglobulin-like receptors, subfamily B (LILRBs) in human diseases: structure, roles, mechanisms, and clinical applications.Theranostics · 2025Review
- Pathogenesis and therapeutic applications of microglia receptors in Alzheimer's disease.Frontiers in immunology · 2025Review
- Leukocyte immunoglobulin-like receptor B4: A keystone in immune modulation and therapeutic target in cancer and beyond.Cancer innovation · 2024Review
- NLRP12/C1qA positive feedback in tumor-associated macrophages regulates immunosuppression through LILRB4/NF-κB pathway in lung adenocarcinoma.Cancer immunology, immunotherapy : CII · 2024Article
Corrections and comments
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Authors and funding
26 authors at 4 institutions in 3 countries.
Jinchao HouDepartment of Pathology and Immunology, Washington University in St. Louis, St. Louis, MO 63110, USA.ORCID 0000-0003-3829-7551
Yun ChenDepartment of Pathology and Immunology, Washington University in St. Louis, St. Louis, MO 63110, USA.ORCID 0000-0003-0547-9463
Zhangying CaiDepartment of Pathology and Immunology, Washington University in St. Louis, St. Louis, MO 63110, USA.ORCID 0009-0003-7810-3827
Gyu Seong HeoDepartment of Radiology, Washington University in St. Louis, St. Louis, MO 63110, USA.ORCID 0000-0001-6200-4742
Carla M YuedeDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-6362-4767
Zuoxu WangDepartment of Pathology and Immunology, Washington University in St. Louis, St. Louis, MO 63110, USA.ORCID 0000-0003-1513-3511
Kent LinDepartment of Pathology and Immunology, Washington University in St. Louis, St. Louis, MO 63110, USA.ORCID 0000-0002-2521-1328
Fareeha SaadiDepartment of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University in St. Louis, St. Louis, MO 63110, USA.ORCID 0000-0003-1004-5950
Tihana TrsanDepartment of Pathology and Immunology, Washington University in St. Louis, St. Louis, MO 63110, USA.ORCID 0000-0002-7549-2885
Aivi T NguyenDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0003-1809-9451
Eleni ConstantopoulosDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0009-0008-9001-1526
Rachel A LarsenDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0009-0001-0780-1439
Yiyang ZhuDepartment of Pathology and Immunology, Washington University in St. Louis, St. Louis, MO 63110, USA.ORCID 0000-0002-0272-1915
Nicole D WagnerDepartment of Chemistry, Washington University in St. Louis, St. Louis, MO 63110, USA.ORCID 0000-0003-3980-4893
Nolan McLaughlinDepartment of Chemistry, Washington University in St. Louis, St. Louis, MO 63110, USA.
Xinyi Cynthia KuangDepartment of Chemistry, Washington University in St. Louis, St. Louis, MO 63110, USA.
Alexander D BarrowDepartment of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Parkville, VIC 3000, Australia.
Dian LiDivision of Nephrology, Department of Medicine, Washington University, St. Louis, MO 63110, USA.ORCID 0000-0002-5374-7314
Yingyue ZhouDepartment of Pathology and Immunology, Washington University in St. Louis, St. Louis, MO 63110, USA.ORCID 0000-0002-0923-1046
Shoutang WangSchool of Biomedical Sciences, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pok Fu Lam, Hong Kong, China.ORCID 0000-0003-1049-9127
Susan GilfillanDepartment of Pathology and Immunology, Washington University in St. Louis, St. Louis, MO 63110, USA.ORCID 0000-0003-1672-0996
Michael L GrossDepartment of Chemistry, Washington University in St. Louis, St. Louis, MO 63110, USA.ORCID 0000-0003-1159-4636
Simone BrioschiDepartment of Pathology and Immunology, Washington University in St. Louis, St. Louis, MO 63110, USA.ORCID 0000-0002-3849-3926
Yongjian LiuDepartment of Radiology, Washington University in St. Louis, St. Louis, MO 63110, USA.ORCID 0000-0002-1118-1535
David M HoltzmanDepartment of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University in St. Louis, St. Louis, MO 63110, USA.ORCID 0000-0002-3400-0856
Marco ColonnaDepartment of Pathology and Immunology, Washington University in St. Louis, St. Louis, MO 63110, USA.ORCID 0000-0001-5222-4987
Washington University in St. Louis · USMayo Clinic · USPeter Doherty Institute · AUUniversity of Hong Kong · HK
Funding
The protein tyrosine kinase SYK drives innate immune responses against Alzheimer's DiseaseP01AG078106 · NIA · WASHINGTON UNIVERSITY · PI Jonathan Kipnis · 2022 to 2026
$18.4MTREM2 IN MICROGLIA BIOLOGY AND ALZHEIMER'S DISEASERF1AG051485 · NIA · WASHINGTON UNIVERSITY · PI COLONNA, MARCO · 2015 to 2021
$3.5MTHERAPEUTIC STRATEGIES FOR ALZHEIMER'S DISEASE BASED ON TREM2 BIOLOGYRF1AG059082 · NIA · WASHINGTON UNIVERSITY · PI COLONNA, MARCO · 2019 to 2019
$2.6MA Biomedical Mass Spectrometry Resource: Ongoing Driving Biomedical ProjectsR24GM136766 · NIGMS · WASHINGTON UNIVERSITY · PI GROSS, MICHAEL L · 2020 to 2022
$2.3MIMPACT OF NOVEL REGULATORS OF TREM2 EXPRESSION ON ALZHEIMER'S DISEASER21AG059176 · NIA · WASHINGTON UNIVERSITY · PI COLONNA, MARCO · 2018 to 2019
$419kNIA NIH HHS P01 AG078106NIA NIH HHS R21 AG059176NIA NIH HHS RF1 AG051485NIA NIH HHS RF1 AG059082NIGMS NIH HHS R24 GM136766
Abstract
Microglia help limit the progression of Alzheimer's disease (AD) by constraining amyloid-β (Aβ) pathology, effected through a balance of activating and inhibitory intracellular signals delivered by distinct cell surface receptors. Human leukocyte Ig-like receptor B4 (LILRB4) is an inhibitory receptor of the immunoglobulin (Ig) superfamily that is expressed on myeloid cells and recognizes apolipoprotein E (ApoE) among other ligands. Here, we find that LILRB4 is highly expressed in the microglia of patients with AD. Using mice that accumulate Aβ and carry a transgene encompassing a portion of the
Indexed as
Alzheimer DiseaseMicrogliaAmyloidAmyloid beta-PeptidesAnimalsAntibodiesApolipoproteins EDisease Models, AnimalHumansLeukocytesMembrane GlycoproteinsMiceMice, TransgenicReceptors, Cell SurfaceReceptors, ImmunologicAmyloidAmyloid beta-PeptidesAntibodiesApolipoproteins ELILRB4 protein, humanMembrane GlycoproteinsReceptors, Cell SurfaceReceptors, Immunologic
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.