Evidence map›Paper›PMID 38569906›Full record

ArticleInternal medicine (Tokyo, Japan)2024

Dapagliflozin-induced Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Followed by Acute Interstitial Nephritis (AIN).

Tomohisa Tsuyuki, Kenta Torigoe, Masatoshi Shimizu, Hiroshi Taira, Ryosuke Sakamoto, Shinichi Abe, Sayaka Kuwatsuka, Kumiko Muta, Hiroshi Mukae, Tomoya Nishino

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Tomohisa TsuyukiDepartment of Nephrology, Nagasaki University Hospital, Japan.
Kenta TorigoeDepartment of Nephrology, Nagasaki University Hospital, Japan.
Masatoshi ShimizuDepartment of Nephrology, Nagasaki University Hospital, Japan.
Hiroshi TairaDepartment of Nephrology, Nagasaki University Hospital, Japan.
Ryosuke SakamotoDepartment of Nephrology, Nagasaki University Hospital, Japan.
Shinichi AbeDepartment of Nephrology, Nagasaki University Hospital, Japan.
Sayaka KuwatsukaDepartment of Dermatology, Nagasaki University Hospital, Japan.
Kumiko MutaDepartment of Nephrology, Nagasaki University Hospital, Japan.
Hiroshi MukaeDepartment of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Tomoya NishinoDepartment of Nephrology, Nagasaki University Hospital, Japan.
Nagasaki University Hospital · JPNagasaki University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 78-year-old male was admitted to the hospital with acute renal failure and generalized erythema after starting dapagliflozin 10 mg/day for chronic kidney disease (CKD). A skin biopsy revealed superficial perivascular dermatitis with eosinophils. A renal biopsy revealed lymphocytic and eosinophilic infiltration of the interstitium, and focal tubulitis. The patient was diagnosed with a dapagliflozin-induced drug reaction with eosinophilia and systemic symptoms (DRESS), followed by acute interstitial nephritis (AIN), and prednisolone therapy was therefore initiated. The patient's renal function improved, and erythema disappeared. To our knowledge, this is the first report of DRESS caused by dapagliflozin, and the patient was successfully treated with prednisolone.

Indexed as

Benzhydryl CompoundsDrug Hypersensitivity SyndromeGlucosidesNephritis, InterstitialPrednisoloneAcute DiseaseAgedEosinophiliaHumansMaleSodium-Glucose Transporter 2 InhibitorsBenzhydryl CompoundsdapagliflozinGlucosidesPrednisoloneSodium-Glucose Transporter 2 Inhibitorsacute interstitial nephritisdrug hypersensitivitydrug reaction with eosinophilia and systemic symptomssodium-glucose cotransporter 2 inhibitors

Identifiers

PMID38569906
PMCPMC11671189
OpenAlexW4393371230

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.