Evidence map›Paper›PMID 38570829›Full record

ArticleJournal of nanobiotechnology2024

GSH-responsive degradable nanodrug for glucose metabolism intervention and induction of ferroptosis to enhance magnetothermal anti-tumor therapy.

Zhen Liao, E Wen, Yi Feng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Zhen LiaoDepartment of Biomedical Engineering, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 61173, Sichuan, People's Republic of China.
E WenPrecision Medicine Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
Yi FengInstitute of Burn Research Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, People's Republic of China. fengxiaoyijoy@163.com.
Army Medical University · CNChongqing Medical University · CNUniversity of Electronic Science and Technology of China · CN

Funding

China Postdoctoral Science Foundation 2023M734260Chongqing Natural Science Foundation for postdoctoral CSTB2023NSCQ-BHX0028Chongqing Natural Science Foundation for postdoctoral CSTB2023NSCQ-BHX0205
6 · The paper itself

Abstract

The challenges associated with activating ferroptosis for cancer therapy primarily arise from obstacles related to redox and iron homeostasis, which hinder the susceptibility of tumor cells to ferroptosis. However, the specific mechanisms of ferroptosis resistance, especially those intertwined with abnormal metabolic processes within tumor cells, have been consistently underestimated. In response, we present an innovative glutathione-responsive magnetocaloric therapy nanodrug termed LFMP. LFMP consists of lonidamine (LND) loaded into PEG-modified magnetic nanoparticles with a Fe

Indexed as

FerroptosisNeoplasmsCell Line, TumorDisulfidesGlucoseGlutathioneHumansIronLactic AcidReactive Oxygen SpeciesTumor MicroenvironmentDisulfidesGlucoseGlutathioneIronLactic AcidReactive Oxygen SpeciesFerroptosisMagnetothermal therapyMesoporous silica nanoparticleMetabolic interferenceRedox homeostasis

Identifiers

PMID38570829
PMCPMC11321096
OpenAlexW4393900820

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.