ArticleScience (New York, N.Y.)2024
Sexual dimorphism in skin immunity is mediated by an androgen-ILC2-dendritic cell axis.
Article in Science (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 84 citations in OpenAlex.
- Lymph node contraction links sex-biased naive CD8Nature aging · 2026Article
- Sex-Biased Immunity: The Hidden Variable in Immuno-oncology.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026Review
- Microbial reactivation of host androgens directs enteric neuronal regulation of gut motility.Nature neuroscience · 2026Article
- Group 2 innate lymphoid cells program pulmonary adaptive immunity via granulocyte-macrophage colony-stimulating factor.The Journal of allergy and clinical immunology · 2026Article
- Systemic testosterone induces structural, immunological, and sex steroid receptor changes in human XX skin.Scientific reports · 2026Article
- Article
- Platelet-macrophage cooperation drives IL-33-dependent type 2 lung immunopathology in a sex-biased manner.The Journal of allergy and clinical immunology · 2026Article
- Activity-guided substructure prioritization accelerates discovery of gut microbiota-derived immune-regulating metabolites.Nature communications · 2026Article
- Characterizing Infiltrating Macrophages in Intracranial Aneurysm with IA Animal Models and Spatial Transcriptomics.Translational stroke research · 2026Review
- Sexual Dimorphism in Allergic and Mast Cell-Associated Diseases.Clinical reviews in allergy & immunology · 2026Review
- Androgens are a Key Factor Affecting Immune Related Diseases.The world journal of men's health · 2026Review
- Sex differences in immune responses to viruses, bacteria and vaccines.Nature immunology · 2026Review
- Endoderm differentiates into a transient epidermis in the mouse perineum.Developmental dynamics : an official publication of the American Association of Anatomists · 2026Article
- Article
- Nanoparticles reveal permanent and reversible changes to lymph node biomechanics during inflammatory response.Biomaterials · 2026Article
- Skin androgens affect virulence of Staphylococcus aureus.Nature microbiology · 2026Article
- Sex Differences in Lung Immunity.Immunological reviews · 2026Review
- Sex Differences in the Impact of Obesity on Immunity.Immunological reviews · 2026Review
- Collagen binding adhesin restricts Staphylococcus aureus skin infection.Nature communications · 2026Article
- Quantitative dissection of sexual dimorphism in mice through Y-linked gene knockouts and multivariate phenotyping.Scientific reports · 2026Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
20 authors at 3 institutions in 3 countries.
Funding
Abstract
Males and females exhibit profound differences in immune responses and disease susceptibility. However, the factors responsible for sex differences in tissue immunity remain poorly understood. Here, we uncovered a dominant role for type 2 innate lymphoid cells (ILC2s) in shaping sexual immune dimorphism within the skin. Mechanistically, negative regulation of ILC2s by androgens leads to a reduction in dendritic cell accumulation and activation in males, along with reduced tissue immunity. Collectively, our results reveal a role for the androgen-ILC2-dendritic cell axis in controlling sexual immune dimorphism. Moreover, this work proposes that tissue immune set points are defined by the dual action of sex hormones and the microbiota, with sex hormones controlling the strength of local immunity and microbiota calibrating its tone.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.