Evidence map›Paper›PMID 38575752›Full record

ReviewNature reviews. Cardiology2024

Uncovering atherosclerotic cardiovascular disease by PET imaging.

Alexander Maier, Abraham J P Teunissen, Sheqouia A Nauta, Esther Lutgens, Zahi A Fayad, Mandy M T van Leent

Abstract readReview
In one paragraph

Review in Nature reviews. Cardiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Review
  3. [EJNMMI research · 2026
    Article
  4. Article
  5. Review
  6. Can Nuclear Imaging Detect Trained Immunity in Cardiovascular Disease?Arteriosclerosis, thrombosis, and vascular biology · 2026
    Review
  7. Review
  8. Radial Hadamard-encodedMagma (New York, N.Y.) · 2025
    Article
  9. Review
  10. Article
  11. Review
  12. Emerging PET radiotracers for vascular imaging.Rheumatology (Oxford, England) · 2025
    Review
  13. Radiopharmaceuticals and their applications in medicine.Signal transduction and targeted therapy · 2025
    Review
  14. Article
  15. Role of Total Body PET/CT in Inflammatory Disorders.Seminars in nuclear medicine · 2025
    Review
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alexander MaierDepartment of Cardiology and Angiology, University Heart Center Freiburg-Bad Krozingen, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany.ORCID 0000-0003-0200-7495
Abraham J P TeunissenBioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sheqouia A NautaBioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Esther LutgensCardiovascular Medicine and Immunology, Experimental Cardiovascular Immunology Laboratory, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-2609-5744
Zahi A FayadBioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-3439-7347
Mandy M T van LeentBioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. mandy.vanleent@mountsinai.org.ORCID 0000-0002-9747-1022

Funding

Translational imaging and nanomedicine in inflammatory atherosclerosisP01HL131478 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Abraham Teunissen · 2017 to 2026
$24.3M
Using trained immunity-inhibiting nanobiologics to achieve tolerance of heart allografts in non-human primatesP01AI168258 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Zahi A. Fayad, Joren C Madsen · 2023 to 2026
$14.7M
PET/MRI imaging of mitral valve prolapseR01HL166720 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI David H Adams, Zahi A. Fayad · 2023 to 2026
$8.2M
Atherosclerosis in cocaine addiction: imaging risk with PET/MRR01DA049547 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Nelly Alia-Klein, Zahi A. Fayad · 2022 to 2026
$3.9M
Preclinical imaging of immune responses to chronic stressR01HL169500 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Mandy Maria Theresia van Leent · 2023 to 2026
$2.5M
NHLBI NIH HHS P01 HL131478NHLBI NIH HHS R01 HL166720NHLBI NIH HHS R01 HL169500NIAID NIH HHS P01 AI168258NIDA NIH HHS R01 DA049547
6 · The paper itself

Abstract

Assessing atherosclerosis severity is essential for precise patient stratification. Specifically, there is a need to identify patients with residual inflammation because these patients remain at high risk of cardiovascular events despite optimal management of cardiovascular risk factors. Molecular imaging techniques, such as PET, can have an essential role in this context. PET imaging can indicate tissue-based disease status, detect early molecular changes and provide whole-body information. Advances in molecular biology and bioinformatics continue to help to decipher the complex pathogenesis of atherosclerosis and inform the development of imaging tracers. Concomitant advances in tracer synthesis methods and PET imaging technology provide future possibilities for atherosclerosis imaging. In this Review, we summarize the latest developments in PET imaging techniques and technologies for assessment of atherosclerotic cardiovascular disease and discuss the relationship between imaging readouts and transcriptomics-based plaque phenotyping.

Indexed as

AtherosclerosisPositron-Emission TomographyHumansPlaque, AtheroscleroticPredictive Value of TestsRadiopharmaceuticalsRadiopharmaceuticals

Identifiers

PMID38575752
PMCPMC11324396

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.