Evidence map›Paper›PMID 38579707›Full record

ArticleStructure (London, England : 1993)2024

MLL4 binds TET3.

Dustin C Becht, Sk Abdul Mohid, Ji-Eun Lee, Mohamad Zandian, Caroline Benz, Soumi Biswas, Vikrant Kumar Sinha, Ylva Ivarsson, Kai Ge, Yi Zhang and 1 more

Abstract read
In one paragraph

Article in Structure (London, England : 1993), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dustin C BechtDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Sk Abdul MohidDepartment of Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Ji-Eun LeeLaboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA.
Mohamad ZandianDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Caroline BenzDepartment of Chemistry - BMC, Uppsala University, 751 23 Uppsala, Sweden.
Soumi BiswasDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Vikrant Kumar SinhaDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Ylva IvarssonDepartment of Chemistry - BMC, Uppsala University, 751 23 Uppsala, Sweden.
Kai GeLaboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA.
Yi ZhangDepartment of Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. Electronic address: yi.zhang26@case.edu.
Tatiana G KutateladzeDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA. Electronic address: tatiana.kutateladze@cuanschutz.edu.

Funding

Regulation of PPARgamma Expression and Adipogenesis by PTIP-Associated FactorsZIADK075003 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI GE, KAI · 2009 to 2025
$17.6M
Targeting acetylated histone H4 by MLL4R01AG067664 · NIA · UNIVERSITY OF COLORADO DENVER · PI KUTATELADZE, TATIANA G · 2021 to 2025
$2.1M
Molecular analysis of ASH1LR01CA252707 · NCI · UNIVERSITY OF COLORADO DENVER · PI TATIANA G KUTATELADZE · 2020 to 2026
$1.9M
Arginyl-tRNA beyond translation: mechanism and regulation of protein arginylationR35GM150678 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI Yi Zhang · 2023 to 2026
$1.9M
The role of JADE in HBO complexesR01HL151334 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI KUTATELADZE, TATIANA G · 2020 to 2023
$1.8M
p62 in Cancer: Mechanism and RegulationR00CA241301 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI ZHANG, YI · 2021 to 2023
$747k
Targeting acetylated histone H4 by MLL4R56AG067664 · NIA · UNIVERSITY OF COLORADO DENVER · PI KUTATELADZE, TATIANA G · 2020 to 2020
$512k
NCI NIH HHS R00 CA241301NCI NIH HHS R01 CA252707NHLBI NIH HHS R01 HL151334NIA NIH HHS R01 AG067664NIA NIH HHS R56 AG067664NIGMS NIH HHS R35 GM150678
6 · The paper itself

Abstract

Human mixed lineage leukemia 4 (MLL4), also known as KMT2D, regulates cell type specific transcriptional programs through enhancer activation. Along with the catalytic methyltransferase domain, MLL4 contains seven less characterized plant homeodomain (PHD) fingers. Here, we report that the sixth PHD finger of MLL4 (MLL4

Indexed as

DioxygenasesDNA-Binding ProteinsHistone-Lysine N-MethyltransferaseProtein BindingAnimalsBinding SitesHumansMiceModels, MolecularMyeloid-Lymphoid Leukemia ProteinProto-Oncogene ProteinsDioxygenasesDNA-Binding ProteinsHistone-Lysine N-MethyltransferaseMLL4 protein, humanMyeloid-Lymphoid Leukemia ProteinProto-Oncogene ProteinsTET3 protein, humaninteractionMLL4PHD fingerstructureTET3

Identifiers

PMID38579707
PMCPMC11162309

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.