Evidence map›Paper›PMID 38580869›Full record

ReviewAngiogenesis2024

The role of vasculature and angiogenesis in respiratory diseases.

Maximilian Ackermann, Christopher Werlein, Edith Plucinski, Sophie Leypold, Mark P Kühnel, Stijn E Verleden, Hassan A Khalil, Florian Länger, Tobias Welte, Steven J Mentzer and 1 more

Abstract readReview
In one paragraph

Review in Angiogenesis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. Article
  2. Role of ZEB1 in angiogenesis and therapeutic potential (Review).International journal of molecular medicine · 2026
    Review
  3. Article
  4. Review
  5. Vascular remodeling in asthma: from mechanisms to precision medicine.Current opinion in allergy and clinical immunology · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. The Human Organ Atlas.Science advances · 2026
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Maximilian AckermannInstitute of Pathology, University Clinics of RWTH University, Aachen, Germany. maximilian.ackermann@uni-mainz.de.
Christopher WerleinInstitute of Pathology, Hannover Medical School, Hannover, Germany.
Edith PlucinskiInstitute of Pathology, Hannover Medical School, Hannover, Germany.
Sophie LeypoldInstitute of Pathology, University Clinics of RWTH University, Aachen, Germany.
Mark P KühnelInstitute of Pathology, University Clinics of RWTH University, Aachen, Germany.
Stijn E VerledenAntwerp Surgical Training, Anatomy and Research Centre (ASTARC), University of Antwerp, Antwerp, Belgium.
Hassan A KhalilDivision of Thoracic and Cardiac Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, USA.
Florian LängerInstitute of Pathology, University Clinics of RWTH University, Aachen, Germany.
Tobias WelteMember of the German Center for Lung Research (DZL), Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Hannover, Germany.
Steven J MentzerDivision of Thoracic and Cardiac Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, USA.
Danny D JonigkInstitute of Pathology, University Clinics of RWTH University, Aachen, Germany.

Funding

Adult Tissue Morphogenesis: Functional Regulation of Intussusceptive AngiogenesisR01HL094567 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MENTZER, STEVEN · 2009 to 2016
$3.2M
Formation of the Elastin Line Element in the Developing LungF32HL134229 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI VALENZUELA, CRISTIAN DAVID · 2016 to 2016
$57k
Chan Zuckerberg Initiative,United States DAF (no. 2020-225394)Deutsche Forschungsgemeinschaft KFO311, Project Z2HORIZON EUROPE European Research Council XHale 771883NHLBI NIH HHS F32 HL134229NHLBI NIH HHS R01 HL094567NIH HHS HL94567
6 · The paper itself

Abstract

In European countries, nearly 10% of all hospital admissions are related to respiratory diseases, mainly chronic life-threatening diseases such as COPD, pulmonary hypertension, IPF or lung cancer. The contribution of blood vessels and angiogenesis to lung regeneration, remodeling and disease progression has been increasingly appreciated. The vascular supply of the lung shows the peculiarity of dual perfusion of the pulmonary circulation (vasa publica), which maintains a functional blood-gas barrier, and the bronchial circulation (vasa privata), which reveals a profiled capacity for angiogenesis (namely intussusceptive and sprouting angiogenesis) and alveolar-vascular remodeling by the recruitment of endothelial precursor cells. The aim of this review is to outline the importance of vascular remodeling and angiogenesis in a variety of non-neoplastic and neoplastic acute and chronic respiratory diseases such as lung infection, COPD, lung fibrosis, pulmonary hypertension and lung cancer.

Indexed as

Neovascularization, PathologicAnimalsHumansLungRespiratory Tract DiseasesVascular RemodelingCOPDCOVID-19ECFCEndothelial mesenchymal transition (EndoMT)Fibrovascular interfaceIntussusceptive angiogenesisPulmonary fibrosisRespiratory diseasesTumor angiogenesisVascular normalization

Identifiers

PMID38580869
PMCPMC11303512

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.