Evidence map›Paper›PMID 38580979›Full record

ReviewRetrovirology2024

The cell biology of HIV-1 latency and rebound.

Uri Mbonye, Jonathan Karn

Open access · goldAbstract readReview
In one paragraph

Review in Retrovirology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
11.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Network Pharmacology-Guided Identification ofInternational journal of molecular sciences · 2026
    Article
  11. Article
  12. Article
  13. Traditional Medicine Extracts ofInternational journal of molecular sciences · 2026
    Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. The STAT Signaling Pathway in HIV-1 Infection: Roles and Dysregulation.International journal of molecular sciences · 2025
    Review
  20. Phytochemicals fromMicroorganisms · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Uri MbonyeDepartment of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA. uri.mbonye@case.edu.
Jonathan KarnDepartment of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA. jonathan.karn@case.edu.
Case Western Reserve University · USUniversity School · US

Funding

WG3: HIV, Co-infections and Co-morbiditiesP30AI036219 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI Immaculate Lillian Nankya · 1994 to 2026
$50.0M
Control of P-TEFb biogenesis and HIV transcription in primary T-cellsR01AI148083 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI KARN, JONATHAN, MBONYE, URI · 2019 to 2023
$2.0M
NIAID NIH HHS P30 AI036219NIAID NIH HHS R01 AI148083
6 · The paper itself

Abstract

Transcriptionally latent forms of replication-competent proviruses, present primarily in a small subset of memory CD4

Indexed as

HIV-1HIV InfectionsCD4-Positive T-LymphocytesHumansPositive Transcriptional Elongation Factor BProvirusesVirus ActivationVirus LatencyPositive Transcriptional Elongation Factor B7SK snRNPEpigenetic silencingHIV-1 latencyHIV-1 reservoirHIV-1 TatLatency reversalP-TEFbT-cell receptor signalingTranscription elongation

Identifiers

PMID38580979
PMCPMC10996279
OpenAlexW4393969911

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.