Evidence map›Paper›PMID 38582718›Full record

ReviewInternational dental journal2024

A Review of Stem Cell Attributes Derived from the Oral Cavity.

Marina Miteva, Zornitsa Mihaylova, Vanyo Mitev, Evgeniy Aleksiev, Pavel Stanimirov, Maria Praskova, Violeta S Dimitrova, Anelia Vasileva, Bogdan Calenic, Ileana Constantinescu and 2 more

Abstract readReview
In one paragraph

Review in International dental journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
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  10. mInternational journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Marina MitevaDepartment of Chemistry and Biochemistry, Medical Faculty, Medical University Sofia, Bulgaria.
Zornitsa MihaylovaDepartment of Dental, Oral and Maxillofacial Surgery, Faculty of Dental Medicine, Medical University Sofia, Bulgaria.
Vanyo MitevDepartment of Chemistry and Biochemistry, Medical Faculty, Medical University Sofia, Bulgaria.
Evgeniy AleksievDepartment of Dental, Oral and Maxillofacial Surgery, Faculty of Dental Medicine, Medical University Sofia, Bulgaria.
Pavel StanimirovDepartment of Dental, Oral and Maxillofacial Surgery, Faculty of Dental Medicine, Medical University Sofia, Bulgaria.
Maria PraskovaDepartment of Chemistry and Biochemistry, Medical Faculty, Medical University Sofia, Bulgaria.
Violeta S DimitrovaDepartment of Chemistry and Biochemistry, Medical Faculty, Medical University Sofia, Bulgaria.
Anelia VasilevaDepartment of Chemistry and Biochemistry, Medical Faculty, Medical University Sofia, Bulgaria.
Bogdan CalenicCentre for Immunogenetics and Virology, Fundeni Clinical Institute, University of Medicine and Farmacy "Carol Davila," Bucharest, Romania. Electronic address: bogdan.calenic@umfcd.ro.
Ileana ConstantinescuCentre for Immunogenetics and Virology, Fundeni Clinical Institute, University of Medicine and Farmacy "Carol Davila," Bucharest, Romania.
Paula PerleaDepartment of Endodontics, UMF Carol Davila, Bucharest, Romania. Electronic address: paulaperlea@gmail.com.
Nikolay IshkitievDepartment of Chemistry and Biochemistry, Medical Faculty, Medical University Sofia, Bulgaria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral cavity stem cells (OCSCs) have been the focus of intense scientific efforts due to their accessibility and stem cell properties. The present work aims to compare the different characteristics of 6 types of dental stem cells derived from the oral cavity: dental pulp stem cells (DPSC), stem cells from human exfoliated deciduous teeth (SHED), periodontal ligament stem cells (PDLSC), stem cells from the apical papilla (SCAP), bone marrow mesenchymal stem cells (BMSC), and gingival mesenchymal stem cells (GMSC). Using immunofluorescence and real-time polymerase chain reaction techniques, we analysed the cells for stem cell, differentiation, adhesion, and extracellular matrix markers; the ability to proliferate in vitro; and multilineage differentiation potential. Markers such as vimentin, CD44, alkaline phosphatase, CD146, CD271, CD49f, Oct 3/4, Sox 9, FGF7, nestin, and BMP4 showed significant differences in expression levels, highlighting the heterogeneity and unique characteristics of each cell type. At the same time, we confirmed that all cell types successfully differentiated into osteogenic, chondrogenic, or adipose lineages, with different readiness. In conclusion, our study reveals the distinct properties and potential applications of various dental-derived stem cells. These findings contribute to a deeper understanding of OCSCs and their significance in future clinical applications.

Indexed as

Cell DifferentiationDental PulpMesenchymal Stem CellsStem CellsBiomarkersDental PapillaGingivaHumansMouthPeriodontal LigamentTooth, DeciduousBiomarkersBone marrow mesenchymal stem cellsDental pulp stem cellsGingival mesenchymal stem cellsPeriodontal ligament cellsStem cells from human exfoliated deciduous teethStem cells from the apical papilla

Identifiers

PMID38582718
PMCPMC11561491

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.