ArticleFrontiers in medicine2024
Serum phosphate levels and the development of sepsis associated acute kidney injury: evidence from two independent databases.
Article in Frontiers in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Article
- Association between admission serum phosphate levels and prognosis in post-cardiac arrest patients: a retrospective observational study.BMC cardiovascular disorders · 2026Observational
- Risk factors and a nomogram for predicting severe acute kidney injury in pediatric sepsis: a retrospective study.Frontiers in pediatrics · 2026Article
- Development and validation of a clinical prediction model for sepsis-induced cardiomyopathy.Frontiers in cardiovascular medicine · 2026Article
- Association between serum phosphate levels and 28-day mortality in patients with sepsis-associated liver injury: a cohort study.BMC infectious diseases · 2025Article
- Association between the lactate-to-albumin ratio and sepsis-associated acute kidney injury: a cross-sectional study.European journal of medical research · 2025Article
- Prognostic Value of SIRI in Sepsis: A Retrospective Study and Machine Learning-Based Model Development.Journal of inflammation research · 2025Article
- Effect of potential risk factors on renal functions in simultaneous bilateral total knee arthroplasty.Frontiers in surgery · 2024Article
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Authors and funding
3 authors.
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Abstract
Objective: We aimed to investigate the association between serum phosphate levels and the risk for developing sepsis associated acute kidney injury (SAKI). Methods: Septic patients from the Medical Information Mart for Intensive Care IV (MIMIC IV) and the eICU Collaborative Research Database (eICU-CRD) were enrolled. Restricted cubic spline (RCS) was used to visualize the relationship between phosphate levels and the risk of SAKI. Patients were divided into four categories based on their serum phosphate levels. Logistic regression analysis, receiver operating characteristic (ROC) curve and subgroup analysis were performed to evaluate the predictive value of serum phosphate for SAKI. Results: A total of 9,244 and 2,124 patients from the MIMIC IV and eICU-CRD database were included in the final analysis. RCS curve revealed a non-linear correlation between phosphate levels and the risk of SAKI ( Conclusion: Elevated serum phosphate, even within the normal range, is an independent risk factor for developing SAKI in septic patients. Abnormal change in serum phosphate levels may be a novel biomarker for early prediction of SAKI occurrence.
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