Evidence map›Paper›PMID 38585537›Full record

ArticleJournal of medicine and life2023

Comparative analysis of immunological biomarkers in COVID-19 and bacterial pneumonia.

Mudathir Abdelshafea Abdelkareem Abakar, Daralnaeem Hassan Ali Hamad, Eman Faisal, Hashim Mohamed Fad-Alla Omer, Mahmoud Taha Mohamed Faki, Abdellla Esmail Mohammed Idris, Rouwida Omer, Zeinab Osman, Entesar Ahmed Gaffar Elhassan, Mohamed Ahmed Abrahim-Holie and 6 more

Abstract read
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In one paragraph

Article in Journal of medicine and life, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Mudathir Abdelshafea Abdelkareem AbakarDepartment of Medical Microbiology and Immunology, Faculty of Medical Laboratory Sciences, Alzaiem Alazhari University, Khartoum, Khartoum State, Sudan.
Daralnaeem Hassan Ali HamadMinistry of Health, Kassala, Kassala State, Sudan.
Eman FaisalDepartment of Microbiology, Faculty of Medical Laboratory, University of Kassala, Kassala, Kassala State, Sudan.
Hashim Mohamed Fad-Alla OmerMedical Laboratory, Diagnostic Center, Kassala, Kassala State, Sudan.
Mahmoud Taha Mohamed FakiPublic Health Laboratory, Ministry of Health, Kassala, Kassala State, Sudan.
Abdellla Esmail Mohammed IdrisMinistry of Health, Kassala, Kassala State, Sudan.
Rouwida OmerMinistry of Health, Kassala, Kassala State, Sudan.
Zeinab OsmanMedical Laboratory, Khartoum, Khartoum State, Sudan.
Entesar Ahmed Gaffar ElhassanMinistry of Health, Kassala, Kassala State, Sudan.
Mohamed Ahmed Abrahim-HolieDepartment of Medical Microbiology and Immunology, Faculty of Medical Laboratory Sciences, Alzaiem Alazhari University, Khartoum, Khartoum State, Sudan.
Mohammed Ageeli HakamiDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences Al-Quwayiyah, Shaqra University, Riyadh, Saudi Arabia.
Abdullah AlghamdiDeparment of Medical Laboratory, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Alkharj, Saudi Arabia.
Abdulaziz AlfahedDeparment of Medical Laboratory, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Alkharj, Saudi Arabia.
Ghfren Suliman AlorainiDeparment of Medical Laboratory, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Alkharj, Saudi Arabia.
Nahed Sail AlharthiDeparment of Medical Laboratory, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Alkharj, Saudi Arabia.
Hisham Ali WaggiallahDeparment of Medical Laboratory, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Alkharj, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronavirus disease 2019 (COVID-19) is a severe and infectious respiratory condition caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). This case-control study aimed to evaluate serum levels of various immunological markers in patients with COVID-19 compared to those with bacterial pneumonia and a healthy control group. Serum samples were collected from adult participants across various COVID-19 isolation centers, including Kassala State and Ahmed Gasim Hospital, between April and June 2021. The study included 70 patients diagnosed with COVID-19, 30 with bacterial pneumonia, and 50 healthy controls. Serum levels of C-reactive protein (CRP), complement components C3 and C4, and cytokines IL-8, IL-10, IL-12, TNF-α, and IFN-γ were measured using standard reagent kits. Serum level of CRP was significantly elevated in both bacterial pneumonia and COVID-19 but significantly higher among patients with bacterial pneumonia. C3 and C4 were also increased in both patient groups, with C3 significantly higher in bacterial pneumonia. IL-8, IL-10, IL-12, TNF-α, and IFN-γ were significantly increased in bacterial pneumonia and SARS-Cov-2 compared to healthy controls. However, IFN-γ was significantly increased among patients with COVID-19 than patients with bacterial pneumonia. This study highlights the potential significant impact of COVID-19 on the immunological biomarkers investigated.

Indexed as

COVID-19Pneumonia, BacterialAdultBiomarkersCase-Control StudiesC-Reactive ProteinCytokinesHumansInterleukin-10Interleukin-12Interleukin-8SARS-CoV-2Tumor Necrosis Factor-alphaBiomarkersC-Reactive ProteinCytokinesInterleukin-10Interleukin-12Interleukin-8Tumor Necrosis Factor-alphabacterial pneumoniaC3C4COVID-19CRPIFN-γIL-10IL-12IL-8TNF-α

Identifiers

PMID38585537
PMCPMC10994609

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.