Evidence map›Paper›PMID 38586011›Full record

ArticlebioRxiv : the preprint server for biology2024

AIBP controls TLR4 inflammarafts and mitochondrial dysfunction in a mouse model of Alzheimer's disease.

Yi Sak Kim, Soo-Ho Choi, Keun-Young Kim, Juliana M Navia-Pelaez, Guy A Perkins, Seunghwan Choi, Jungsu Kim, Nicolaus Nazarenkov, Robert A Rissman, Won-Kyu Ju and 2 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Yi Sak KimDepartment of Medicine, University of California, San Diego, La Jolla, CA, 92093, USA.
Soo-Ho ChoiDepartment of Medicine, University of California, San Diego, La Jolla, CA, 92093, USA.
Keun-Young KimNational Center for Microscopy and Imaging Research, Department of Neurosciences, University of California San Diego, La Jolla, CA, 92093, USA.
Juliana M Navia-PelaezDepartment of Medicine, University of California, San Diego, La Jolla, CA, 92093, USA.
Guy A PerkinsNational Center for Microscopy and Imaging Research, Department of Neurosciences, University of California San Diego, La Jolla, CA, 92093, USA.
Seunghwan ChoiHamilton Glaucoma Center and Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, CA, 92093, USA.
Jungsu KimDepartment of Medicine, University of California, San Diego, La Jolla, CA, 92093, USA.
Nicolaus NazarenkovDepartment of Medicine, University of California, San Diego, La Jolla, CA, 92093, USA.
Robert A RissmanDepartment of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-9245-8278
Won-Kyu JuHamilton Glaucoma Center and Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, CA, 92093, USA.
Mark H EllismanNational Center for Microscopy and Imaging Research, Department of Neurosciences, University of California San Diego, La Jolla, CA, 92093, USA.
Yury I MillerDepartment of Medicine, University of California, San Diego, La Jolla, CA, 92093, USA.
University of California San Diego · US

Funding

USCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI · 2020 to 2026
$27.8M
Project 4: APOB-specific CD4 and CD8 T cells exacerbate atherosclerosisP01HL136275 · NHLBI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Catherine C Hedrick · 2017 to 2026
$25.5M
U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
National Center for Microscopy and Imaging Research: A BRAIN Technology Integration and Dissemination ResourceU24NS120055 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELLISMAN, MARK H · 2021 to 2025
$5.4M
3D Reconstruction and Analysis of Alzheimer's Patient Biopsy Samples to Map and Quantify Hallmarks of Pathogenesis and VulnerabilityR01AG065549 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELLISMAN, MARK H · 2020 to 2024
$4.1M
Reversing Microglial Inflammarafts and Mitochondrial Dysfunction in Alzheimer's DiseaseR01AG081037 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Mark H Ellisman, WONKYU JU · 2023 to 2026
$3.1M
Scalable electron tomography for connectomicsRF1MH129261 · NIMH · HARVARD MEDICAL SCHOOL · PI ELLISMAN, MARK H, LEE, WEI-CHUNG ALLEN · 2022 to 2022
$2.9M
Circadian Structural Plasticity in Central PacemakersR01NS108934 · NINDS · UNIVERSITY OF WASHINGTON · PI CERIANI, MARIA FERNANDA, DE LA IGLESIA, HORACIO O · 2020 to 2024
$2.9M
Mitochondrial Protection in Glaucomatous Optic NeuropathyR01EY031697 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JU, WONKYU, PERKINS, GUY A · 2020 to 2023
$2.7M
AIBP-mediated neuroprotection in glaucomatous optic neuropathyR01EY034116 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SOO-HO CHOI, WONKYU JU · 2023 to 2026
$2.6M
The complex interaction between Alzheimer drivers and agingRF1AG062479 · NIA · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI KOSIK, KENNETH STEPHEN · 2020 to 2020
$2.6M
FEI TITAN HALO 300kV INTERMEDIATE VOLTAGE ELECTRON MICROSCOPES10OD021784 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELLISMAN, MARK H · 2017 to 2017
$1.9M
BLRD VA I01 BX004848BLRD VA IK6 BX005224NEI NIH HHS R01 EY031697NEI NIH HHS R01 EY034116NHLBI NIH HHS P01 HL136275NIA NIH HHS P30 AG066530NIA NIH HHS R01 AG062479NIA NIH HHS R01 AG065549NIA NIH HHS R01 AG081037NIA NIH HHS R41 AG081004NIA NIH HHS R56 AG062479NIA NIH HHS RF1 AG062479NIGMS NIH HHS R01 GM138780NIH HHS S10 OD021784NIMH NIH HHS RF1 MH129261NINDS NIH HHS P30 NS047101NINDS NIH HHS R01 NS108934NINDS NIH HHS U24 NS120055NINDS NIH HHS UG3 NS129684
6 · The paper itself

Abstract

Microglia-driven neuroinflammation plays an important role in the development of Alzheimer's disease (AD). Microglia activation is accompanied by the formation and chronic maintenance of TLR4 inflammarafts, defined as enlarged and cholesterol-rich lipid rafts serving as an assembly platform for TLR4 dimers and complexes of other inflammatory receptors. The secreted apoA-I binding protein (APOA1BP or AIBP) binds TLR4 and selectively targets cholesterol depletion machinery to TLR4 inflammaraft expressing inflammatory, but not homeostatic microglia. Here we demonstrated that amyloid-beta (Aβ) induced formation of TLR4 inflammarafts in microglia in vitro and in the brain of APP/PS1 mice. Mitochondria in

Indexed as

AIBPAlzheimer’s diseaseinflammaraftlipid raftsmicrogliamitochondrianeuroinflammationoxidative stressTLR4

Identifiers

PMID38586011
PMCPMC10996524
OpenAlexW4392201341

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.