Evidence map›Paper›PMID 38590761›Full record

ArticleBrain, behavior, & immunity - health2024

Cholesterol-dependent LXR transcription factor activity represses pronociceptive effects of estrogen in sensory neurons and pain induced by myelin basic protein fragments.

Swathi K Hullugundi, Jennifer Dolkas, Andrei V Chernov, Tony L Yaksh, Kelly A Eddinger, Mila Angert, Glaucilene Ferreira Catroli, Alex Y Strongin, Patrick M Dougherty, Yan Li and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, & immunity - health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Pain kept under wraps of myelin sheath.Frontiers in pain research (Lausanne, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Swathi K HullugundiDepartment of Anesthesiology, University of California, San Diego, La Jolla, CA, USA.
Jennifer DolkasDepartment of Anesthesiology, University of California, San Diego, La Jolla, CA, USA.
Andrei V ChernovDepartment of Anesthesiology, University of California, San Diego, La Jolla, CA, USA.
Tony L YakshDepartment of Anesthesiology, University of California, San Diego, La Jolla, CA, USA.
Kelly A EddingerDepartment of Anesthesiology, University of California, San Diego, La Jolla, CA, USA.
Mila AngertDepartment of Anesthesiology, University of California, San Diego, La Jolla, CA, USA.
Glaucilene Ferreira CatroliDepartment of Anesthesiology, University of California, San Diego, La Jolla, CA, USA.
Alex Y StronginSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Patrick M DoughertyDepartment of Pain Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Yan LiDepartment of Pain Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Oswal QuehenbergerLipidomics Core, University of California, San Diego, La Jolla, CA, USA.
Aaron ArmandoLipidomics Core, University of California, San Diego, La Jolla, CA, USA.
Veronica I ShubayevDepartment of Anesthesiology, University of California, San Diego, La Jolla, CA, USA.
University of California San Diego · USThe University of Texas MD Anderson Cancer Center · USSanford Burnham Prebys Medical Discovery Institute · US

Funding

Proteolysis of Myelin as a Source of Neuropathic PainR01DE022757 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SHUBAYEV, VERONICA · 2012 to 2022
$7.3M
BLRD VA I01 BX000638NIDCR NIH HHS R01 DE022757
6 · The paper itself

Abstract

Background: A bioactive myelin basic protein (MBP) fragment, comprising MBP Methods: In male and female normal and post-CCI rat sciatic nerves, we assessed: (i) cholesterol precursor and metabolite levels by lipidomics; (ii) MBP Results: CCI regulated LXRα ligand and receptor levels in nerves of both sexes, with cholesterol precursors, desmosterol and 7-DHC, and oxysterol elevated in females relative to males. MBP Conclusion: The injury-released bioactive MBP fragments induce pronociceptive changes by selective inactivation of nuclear transcription factors, including LXRα. By Ncoa1 sequestration, bioactive MBP fragments render LXRα function to counteract pronociceptive activity of estrogen/ESR1 in sensory neurons. This effect of MBP fragments is prevalent in females due to high circulating estrogen levels in females relative to males. Restoring LXR activity presents a promising therapeutic strategy in management of neuropathic pain induced by bioactive MBP.

Indexed as

CholesterolDRG cultureEstrogenInterleukin 6Liver x receptorLXRMyelin basic proteinNeuropathic painOxysterolSensory neuron

Identifiers

PMID38590761
PMCPMC10999831
OpenAlexW4393344222

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.