Evidence map›Paper›PMID 38593310›Full record

ArticleMicrobial biotechnology2024

Do microbes play a role in Alzheimer's disease?

Zoë A P Williams, Leonie Lang, Sarah Nicolas, Gerard Clarke, John Cryan, David Vauzour, Yvonne M Nolan

Open access · goldAbstract read
In one paragraph

Article in Microbial biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Microbes Saving Lives and Reducing Suffering.Microbial biotechnology · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Zoë A P WilliamsDepartment of Anatomy and Neuroscience, University College Cork, Cork, Ireland.
Leonie LangNorwich Medical School, Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, UK.
Sarah NicolasDepartment of Anatomy and Neuroscience, University College Cork, Cork, Ireland.
Gerard ClarkeAPC Microbiome Ireland, University College Cork, Cork, Ireland.
John CryanDepartment of Anatomy and Neuroscience, University College Cork, Cork, Ireland.
David VauzourNorwich Medical School, Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, UK.ORCID 0000-0001-5952-8756
Yvonne M NolanDepartment of Anatomy and Neuroscience, University College Cork, Cork, Ireland.
University College Cork · IEUniversity of East Anglia · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease is a complex and progressive condition that affects essential neurological functions such as memory and reasoning. In the brain, neuronal loss, synaptic dysfunction, proteinopathy, neurofibrillary tangles, and neuroinflammation are the hallmarks of Alzheimer's disease pathophysiology. In addition, recent evidence has highlighted that microbes, whether commensal or pathogenic, also have the ability to interact with their host and to regulate its immune system, therefore participating in the exchanges that lead to peripheral inflammation and neuropathology. Because of this intimate relationship, bacteria, viruses, fungi, and protozoa have been implicated in the development of Alzheimer's disease. Here, we bring together current and most recent evidence of the role of microbes in Alzheimer's disease, raising burning questions that need to be addressed to guide therapeutic approaches and potential prophylactic strategies.

Indexed as

Alzheimer DiseaseBrainHumansInflammationNeurofibrillary Tangles

Identifiers

PMID38593310
PMCPMC11003713
OpenAlexW4394622582

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.