Evidence map›Paper›PMID 38594355›Full record

ReviewCommunications chemistry2024

Self-assembly of stabilized droplets from liquid-liquid phase separation for higher-order structures and functions.

Mehwish Naz, Lin Zhang, Chong Chen, Shuo Yang, Hongjing Dou, Stephen Mann, Jianwei Li

Abstract readReview
In one paragraph

Review in Communications chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
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  6. Article
  7. Review
  8. Article
  9. Review
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  11. Active Armoring of Protocell Condensates with Metal-Phenolic Networks.Small (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Coacervation in systems chemistry.Communications chemistry · 2024
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mehwish Naz *State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.ORCID http://orcid.org/0000-0001-8963-260X
Lin Zhang *State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.
Chong ChenMediCity Research Laboratory, University of Turku, Tykistökatu 6, Turku, 20520, Finland.
Shuo YangState Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China. sjtu1578252@sjtu.edu.cn.ORCID http://orcid.org/0009-0001-0963-5737
Hongjing DouState Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China. hjdou@sjtu.edu.cn.ORCID http://orcid.org/0000-0001-5850-9174
Stephen MannState Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China. s.mann@bristol.ac.uk.ORCID http://orcid.org/0000-0003-3012-8964
Jianwei LiMediCity Research Laboratory, University of Turku, Tykistökatu 6, Turku, 20520, Finland. jianwei.li@utu.fi.ORCID http://orcid.org/0000-0002-3682-6934

Funding

Academy of Finland (Suomen Akatemia) 355798Sigrid Juséliuksen Säätiö (Sigrid Jusélius Foundation) Senior Researcher Fellowship
6 · The paper itself

Abstract

Dynamic microscale droplets produced by liquid-liquid phase separation (LLPS) have emerged as appealing biomaterials due to their remarkable features. However, the instability of droplets limits the construction of population-level structures with collective behaviors. Here we first provide a brief background of droplets in the context of materials properties. Subsequently, we discuss current strategies for stabilizing droplets including physical separation and chemical modulation. We also discuss the recent development of LLPS droplets for various applications such as synthetic cells and biomedical materials. Finally, we give insights on how stabilized droplets can self-assemble into higher-order structures displaying coordinated functions to fully exploit their potentials in bottom-up synthetic biology and biomedical applications.

Identifiers

PMID38594355
PMCPMC11004187

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.