Evidence map›Paper›PMID 38594515›Full record

ArticlePsychopharmacology2024

5-HT 2A and 5-HT 2C receptor antagonism differentially modulate reinforcement learning and cognitive flexibility: behavioural and computational evidence.

Mona El-Sayed Hervig, Katharina Zühlsdorff, Sarah F Olesen, Benjamin Phillips, Tadej Božič, Jeffrey W Dalley, Rudolf N Cardinal, Johan Alsiö, Trevor W Robbins

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychopharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mona El-Sayed Hervig *Department of Psychology, University of Cambridge, Cambridge, CB2 3EB, UK.
Katharina Zühlsdorff *Department of Psychology, University of Cambridge, Cambridge, CB2 3EB, UK. kz294@cam.ac.uk.
Sarah F OlesenUCL Sainsbury Wellcome Centre for Neural Circuits and Behaviour, London, W1T 4JG, UK.
Benjamin PhillipsDepartment of Psychology, University of Cambridge, Cambridge, CB2 3EB, UK.
Tadej BožičUCL Sainsbury Wellcome Centre for Neural Circuits and Behaviour, London, W1T 4JG, UK.
Jeffrey W DalleyDepartment of Psychology, University of Cambridge, Cambridge, CB2 3EB, UK.
Rudolf N CardinalBehavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, CB2 3EB, UK.
Johan AlsiöDepartment of Psychology, University of Cambridge, Cambridge, CB2 3EB, UK.
Trevor W RobbinsDepartment of Psychology, University of Cambridge, Cambridge, CB2 3EB, UK.

Funding

Alan Turing Institute Alan Turing InstituteLundbeck Foundation R182-2014-2810Medical Research Council MR/N02530X/1Medical Research Council MR/W014386/1Wellcome TrustWellcome Trust 104631/Z/14/Z
6 · The paper itself

Abstract

rationaleCognitive flexibility, the ability to adapt behaviour in response to a changing environment, is disrupted in several neuropsychiatric disorders, including obsessive-compulsive disorder and major depressive disorder. Evidence suggests that flexibility, which can be operationalised using reversal learning tasks, is modulated by serotonergic transmission. However, how exactly flexible behaviour and associated reinforcement learning (RL) processes are modulated by 5-HT action on specific receptors is unknown.

objectivesWe investigated the effects of 5-HT

methodsThirty-six male Lister hooded rats were trained on a touchscreen visual discrimination and reversal task. We evaluated the effects of systemic treatments with the 5-HT

results5-HT

conclusionsThese data indicate that 5-HT

Indexed as

CognitionPiperidinesReceptor, Serotonin, 5-HT2AReceptor, Serotonin, 5-HT2CReinforcement, PsychologyReversal LearningSerotonin 5-HT2 Receptor AntagonistsAminopyridinesAnimalsBehavior, AnimalDose-Response Relationship, DrugFluorobenzenesIndolesMaleRats6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indolineAminopyridinesFluorobenzenesIndolesPiperidinesReceptor, Serotonin, 5-HT2AReceptor, Serotonin, 5-HT2CSerotonin 5-HT2 Receptor Antagonistsvolinanserin5-HT receptorsCognitive flexibilityPunishment learningReinforcement learningReward learningStickiness

Identifiers

PMID38594515
PMCPMC11269483

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.