Evidence map›Paper›PMID 38596059›Full record

ArticleHeliyon2024

Spatiotemporal development of the neuronal accumulation of amyloid precursor protein and the amyloid plaque formation in the brain of 3xTg-AD mice.

Munenori Ono, Tetsufumi Ito, Sachiko Yamaki, Yoshie Hori, Qing Zhou, Xirun Zhao, Shinji Muramoto, Ryo Yamamoto, Takafumi Furuyama, Hiromi Sakata-Haga and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Rebalancing Immune Interactions within the Brain-Spleen Axis Mitigates Neuroinflammation in an Aging Mouse Model of Alzheimer's Disease.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Munenori OnoDepartment of Physiology, Kanazawa Medical University, Ishikawa, 920-0293, Japan.
Tetsufumi ItoSystems Function and Morphology, University of Toyama, Toyama, 930-0194, Japan.
Sachiko YamakiDepartment of Physiology, Kanazawa Medical University, Ishikawa, 920-0293, Japan.
Yoshie HoriDepartment of Physiology, Kanazawa Medical University, Ishikawa, 920-0293, Japan.
Qing ZhouDepartment of Physiology, Kanazawa Medical University, Ishikawa, 920-0293, Japan.
Xirun ZhaoDepartment of Physiology, Kanazawa Medical University, Ishikawa, 920-0293, Japan.
Shinji MuramotoDepartment of Physiology, Kanazawa Medical University, Ishikawa, 920-0293, Japan.
Ryo YamamotoDepartment of Physiology, Kanazawa Medical University, Ishikawa, 920-0293, Japan.
Takafumi FuruyamaDepartment of Physiology, Kanazawa Medical University, Ishikawa, 920-0293, Japan.
Hiromi Sakata-HagaDepartment of Anatomy, Kanazawa Medical University, Ishikawa, 920-0293, Japan.
Toshihisa HattaDepartment of Anatomy, Kanazawa Medical University, Ishikawa, 920-0293, Japan.
Tsuyoshi HamaguchiDepartment of Neurology, Kanazawa Medical University, Ishikawa, 920-0293, Japan.
Nobuo KatoDepartment of Physiology, Kanazawa Medical University, Ishikawa, 920-0293, Japan.
Kanazawa Medical University · JPUniversity of Toyama · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The amyloid plaque is a hallmark of Alzheimer's disease. The accumulation of the amyloid precursor protein (APP) in the neuronal structure is assumed to lead to amyloid plaque formation through the excessive production of β-amyloid protein. To study the relationship between the neuronal accumulation of APP and amyloid plaque formation, we histologically analyzed their development in the different brain regions in 3xTg-AD mice, which express Swedish mutated APP (APP

Indexed as

Alzheimer's diseaseAmyloid precursor proteinImmunohistochemistryTransgenic animalβ-amyloid

Identifiers

PMID38596059
PMCPMC11002285
OpenAlexW4393339881

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.