ArticleScience advances2024
Evidence that the woman's ovarian cycle is driven by an internal circamonthly timing system.
Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed.
- Evolutionary and physiological arguments for the existence of a circalunar clock in humans.BMC ecology and evolution · 2026Review
- Identifying menstrual metrics as personal health markers: Age trends and individual footprints in temperature across 5674 cycles.Science advances · 2026Article
- An Overview of the Impact of the Menstrual Cycle on Nutrient Metabolism: An Integrative Perspective.Nutrients · 2026Review
- Differential effects of sex and age on daily and infradian rhythms of mice.The Journal of physiology · 2026Article
- Lunar gravity predicts sleep timing.bioRxiv : the preprint server for biology · 2026Article
- Associations of meal timing and sleep timing with premenstrual syndrome and dysmenorrhea in Japanese women: a cross-sectional study.Frontiers in nutrition · 2026Article
- Integrative Network View of PCOS: Organ Crosstalk Driven by the Hyperandrogenemia-Insulin Resistance-Inflammation Triad.Journal of multidisciplinary healthcare · 2026Review
- Synchronization of women's menstruation with the Moon has decreased but remains detectable when gravitational pull is strong.Science advances · 2025Article
- Characteristics and health factors influencing menstrual changes after COVID-19 vaccination: A Spanish retrospective observational study in currently menstruating women.Women's health (London, England)Observational
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ovarian cycle has a well-established circa-monthly rhythm, but the mechanisms involved in its regularity are unknown. Is the rhythmicity driven by an endogenous clock-like timer or by other internal or external processes? Here, using two large epidemiological datasets (26,912 cycles from 2303 European women and 4786 cycles from 721 North American women), analyzed with time series and circular statistics, we find evidence that the rhythmic characteristics of the menstrual cycle are more likely to be explained by an endogenous clock-like driving mechanism than by any other internal or external process. We also show that the menstrual cycle is weakly but significantly influenced by the 29.5-day lunar cycle and that the phase alignment between the two cycles differs between the European and the North American populations. Given the need to find efficient treatments of subfertility in women, our results should be confirmed in larger populations, and chronobiological approaches to optimize the ovulatory cycle should be evaluated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.