Evidence map›Paper›PMID 38598637›Full record

ArticleScience advances2024

[

Hye Jin Lee, Ksenija Bernau, Thomas J Harr, Zachary T Rosenkrans, Grace A Kessler, Kristen Stott, Angie Tebon Oler, Babita Rahar, Terry Zhu, Yadira Medina-Guevara and 12 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Exosomes are specialized vehicles to induce fibronectin assembly.bioRxiv : the preprint server for biology · 2025
    Article
  4. Review
  5. Targeting Extra Domain A of Fibronectin to Improve Noninvasive Detection of Triple-Negative Breast Cancer.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  6. Molecular Imaging of Pulmonary Fibrosis.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 1 institution in 1 country.

Hye Jin LeePharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Avenue, Madison, WI 53705, USA.ORCID 0009-0004-9639-9139
Ksenija BernauDivision of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, 600 Highland Avenue, Madison, WI 53792, USA.ORCID 0000-0002-3924-2969
Thomas J HarrDivision of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, 600 Highland Avenue, Madison, WI 53792, USA.
Zachary T RosenkransDepartment of Medical Physics, School of Medicine and Public Health, University of Wisconsin-Madison, 1111 Highland Avenue, Madison, WI 53705, USA.
Grace A KesslerDivision of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, 600 Highland Avenue, Madison, WI 53792, USA.ORCID 0009-0006-5759-7524
Kristen StottDivision of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, 600 Highland Avenue, Madison, WI 53792, USA.
Angie Tebon OlerDivision of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, 600 Highland Avenue, Madison, WI 53792, USA.ORCID 0009-0008-5849-2091
Babita RaharDivision of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, 600 Highland Avenue, Madison, WI 53792, USA.ORCID 0009-0000-9254-1696
Terry ZhuDivision of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, 600 Highland Avenue, Madison, WI 53792, USA.
Yadira Medina-GuevaraDepartment of Medical Physics, School of Medicine and Public Health, University of Wisconsin-Madison, 1111 Highland Avenue, Madison, WI 53705, USA.ORCID 0000-0002-1700-5436
Nikesh GuptaPharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Avenue, Madison, WI 53705, USA.ORCID 0000-0001-6678-5355
Inyoung ChoPharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Avenue, Madison, WI 53705, USA.
Metti K GariDepartment of Cell and Regenerative Biology, School of Medicine and Public Health, University of Wisconsin-Madison, 1111 Highland Avenue, Madison, WI 53705, USA.ORCID 0000-0002-6381-3696
Brian M BurkelDepartment of Cell and Regenerative Biology, School of Medicine and Public Health, University of Wisconsin-Madison, 1111 Highland Avenue, Madison, WI 53705, USA.ORCID 0000-0002-4170-3808
Justin J JefferyUniversity of Wisconsin Carbone Cancer Center, University of Wisconsin-Madison, 1111 Highland Avenue, Madison, WI, USA.
Ashley M WeichmannUniversity of Wisconsin Carbone Cancer Center, University of Wisconsin-Madison, 1111 Highland Avenue, Madison, WI, USA.ORCID 0000-0002-5615-6050
Bianca R Tomasini-JohanssonDivision of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, 600 Highland Avenue, Madison, WI 53792, USA.
Suzanne M PonikDepartment of Cell and Regenerative Biology, School of Medicine and Public Health, University of Wisconsin-Madison, 1111 Highland Avenue, Madison, WI 53705, USA.ORCID 0000-0003-1367-4349
Jonathan W EngleDepartment of Medical Physics, School of Medicine and Public Health, University of Wisconsin-Madison, 1111 Highland Avenue, Madison, WI 53705, USA.ORCID 0000-0002-3399-7228
Reinier HernandezDepartment of Medical Physics, School of Medicine and Public Health, University of Wisconsin-Madison, 1111 Highland Avenue, Madison, WI 53705, USA.ORCID 0000-0002-0729-2179
Glen S KwonPharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Avenue, Madison, WI 53705, USA.
Nathan SandboDivision of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, 600 Highland Avenue, Madison, WI 53792, USA.ORCID 0000-0002-5732-4589
University of Wisconsin–Madison · US

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Justine Yang Bruce · 1985 to 2026
$142.6M
U.W. RADIOLOGICAL SCIENCES TRAINING PROGRAMT32CA009206 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Bryan Patrick Bednarz · 1985 to 2026
$12.1M
Exosome secretion in breast cancer progressionR01CA206458 · NCI · VANDERBILT UNIVERSITY · PI PONIK, SUZANNE MARIE, WEAVER, ALISSA M · 2016 to 2025
$4.6M
Elucidating tensin1-associated signals that promote fibronectin matrix assembly and lung fibrosisR01HL146402 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI SANDBO, NATHAN K · 2019 to 2023
$1.7M
Oligo(lactic acid)n-Prodrug Nanomedicines for Combination TherapyR01CA257837 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI KWON, GLEN S. · 2021 to 2024
$1.4M
Direct therapeutic intervention of the tumor microenvironment with a potent inhibitor of fibronectin assemblyR21CA252579 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI KWON, GLEN S., PONIK, SUZANNE MARIE · 2021 to 2022
$386k
Automated Tissue MicroarrayerS10OD023526 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI MATKOWSKYJ, KRISTINA A. · 2018 to 2018
$184k
NCI NIH HHS P30 CA014520NCI NIH HHS R01 CA206458NCI NIH HHS R01 CA257837NCI NIH HHS R21 CA252579NCI NIH HHS T32 CA009206NHLBI NIH HHS R01 HL146402NIH HHS S10 OD023526
6 · The paper itself

Abstract

Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease resulting in irreversible scarring within the lungs. However, the lack of biomarkers that enable real-time assessment of disease activity remains a challenge in providing efficient clinical decision-making and optimal patient care in IPF. Fibronectin (FN) is highly expressed in fibroblastic foci of the IPF lung where active extracellular matrix (ECM) deposition occurs. Functional upstream domain (FUD) tightly binds the N-terminal 70-kilodalton domain of FN that is crucial for FN assembly. In this study, we first demonstrate the capacity of PEGylated FUD (PEG-FUD) to target FN deposition in human IPF tissue ex vivo. We subsequently radiolabeled PEG-FUD with

Indexed as

Idiopathic Pulmonary FibrosisAnimalsBleomycinHumansLungMicePeptidesTissue DistributionBleomycinPeptides

Identifiers

PMID38598637
PMCPMC11006221
OpenAlexW4394706902

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.