ArticleNature2024
ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 164 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
164citing papers in PubMed, 1 pooled it
46.1field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
164 citing papers in PubMed, 1 synthesis or guideline pooled it, 197 citations in OpenAlex.
- Research trends and topics on sepsis immunosuppression: a bibliometric and visual analysis of global research from 2004 to 2024.Frontiers in medicine · 2025Pooled it
- The role of protein palmitoylation in disease pathogenesis and therapeutic innovation.Annals of medicine · 2026Review
- The gasdermin family: from pyroptosis mechanisms to therapeutic targets.Signal transduction and targeted therapy · 2026Review
- Igniting antitumour immunity with cancer cell pyroptosis.Nature reviews. Cancer · 2026Review
- Topological Quantum Biomaterials Enable Pyroptosis-Senescence Coupling for Enhanced Colorectal Cancer Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A New Gain-of-Function NLRP1 Variant Is Associated with Inflammasome Activation and Disease Severity in SLC25A38 Congenital Sideroblastic Anemia Case Report.Journal of personalized medicine · 2026Article
- Article
- Targeting Gasdermins for Therapeutic Interventions in Central Nervous System Injury.Neurotoxicity research · 2026Review
- Metabolic exhaustion and immune ageing in rheumatoid arthritis.Nature reviews. Rheumatology · 2026Review
- Structural basis of GSDME pore formation and its regulation by S-palmitoylation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Metabolism, autophagy, and cell death: The triangular axis in tumor survival and therapeutic resistance.Redox biology · 2026Review
- Mechanism and plasticity of primitive pyroptosis.Science advances · 2026Article
- Evolution of botulinum neurotoxin serotype X proteases to induce inflammatory cell death in cancer cells.Nature biotechnology · 2026Article
- Gasdermin-Mediated Pyroptosis: Novel Strategies Against Colorectal Cancer.Cancer science · 2026Review
- ZDHHC17-Mediated CDK4 Palmitoylation Drives Cell Cycle Progression and Orchestrates Cancer Immune Surveillance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Mitochondrial STING Governs Glycolytic Reprogramming in Diabetic Cardiomyopathy.Circulation research · 2026Article
- Theme and variations: activation and regulation of gasdermin-mediated inflammation.Biochemical Society transactions · 2026Review
- Kinetic control of macrophage death by PTM-turnover crosstalk in infection and inflammation.Cell chemical biology · 2026Review
- Pyroptosis: Molecular mechanisms and function.Journal of physiology and biochemistry · 2026Review
- Article
104 more citing papers are in PubMed but not listed here.
Corrections and comments
- Update of
Authors and funding
23 authors at 5 institutions in 3 countries.
Gang Du *Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. gdu@crystal.harvard.edu.ORCID 0000-0003-0805-4778
Liam B Healy *Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-2640-1596
Liron DavidDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. david@crystal.harvard.edu.ORCID 0000-0002-9750-543X
Caitlin WalkerDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-0977-8276
Tarick J El-BabaDepartment of Chemistry, University of Oxford, Oxford, UK.ORCID 0000-0003-4497-9938
Corinne A LutomskiDepartment of Chemistry, University of Oxford, Oxford, UK.ORCID 0000-0001-7509-103X
Byoungsook GohCenter for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-7894-7259
Bowen GuProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0003-2629-9963
Xiong PiDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-8835-6914
Pascal DevantHarvard Medical School and Division of Gastroenterology, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0001-9743-6764
Pietro FontanaDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-3215-3784
Ying DongDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
Xiyu MaProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
Rui MiaoProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
Arumugam BalasubramanianDepartment of Pathology, Dana-Farber/Harvard Cancer Center, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-7333-8542
Robbins PuthenveetilSection on Structural and Chemical Biology, Neurosciences and Cellular and Structural Biology Division, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Anirban BanerjeeSection on Structural and Chemical Biology, Neurosciences and Cellular and Structural Biology Division, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-1494-6801
Hongbo R LuoDepartment of Pathology, Dana-Farber/Harvard Cancer Center, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-8545-0451
Jonathan C KaganHarvard Medical School and Division of Gastroenterology, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0003-2364-2746
Sungwhan F OhCenter for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-0280-7903
Carol V RobinsonDepartment of Chemistry, University of Oxford, Oxford, UK.ORCID 0000-0001-7829-5505
Judy LiebermanProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0002-6200-4715
Hao WuDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. wu@crystal.harvard.edu.ORCID 0000-0002-7281-8579
Boston Children's Hospital · USUniversity of Oxford · GBBrigham and Women's Hospital · USNational Institutes of Health · USBen-Gurion University of the Negev · IL
Funding
Structural and chemical biology of membrane proteinsZIAHD008928 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI BANERJEE, ANIRBAN · 2013 to 2025
$34.5MSTRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI JONATHAN C KAGAN · 1986 to 2026
$32.4MNovel Strategies to Improve Blood Transfusion PracticeP01HL158688 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Hongbo R Luo · 2022 to 2026
$12.9MNLRP1 and CARD8 Inflammasomes: Assembly, Regulation and Stress SensingR01AI124491 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI WU, HAO · 2016 to 2025
$5.1MSMOCs: Novel Signal Transduction Complexes as New Targets for Drug DiscoveryDP1HD087988 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI WU, HAO · 2015 to 2019
$4.4MRegulation of immunity by the cGAS-STING pathwayR01AI167993 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI JONATHAN C KAGAN · 2022 to 2026
$3.9MDefining the pathways activated by Toll-like Receptors to stimulate immunityR37AI116550 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI JONATHAN C KAGAN · 2021 to 2026
$3.3MElucidating structural and functional mechanisms of pyroptosisR01AI182369 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI Hao Wu · 2024 to 2026
$2.6MElucidating the structural mechanism of pore formation by the (GSDM) Gasdermin familyR01AI139914 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI WU, HAO · 2018 to 2022
$2.6MGasdermin E and pyroptosis in cancerR01CA240955 · NCI · BOSTON CHILDREN'S HOSPITAL · PI LIEBERMAN, JUDY · 2020 to 2024
$2.5MCharacterization of the myddosome, a protein complex that controls TLR signalingR01AI116550 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI KAGAN, JONATHAN C · 2017 to 2020
$1.8MContribution of phytochemicals to gut symbiont colonization and synthesis of immunomodulatory sphingolipidsR01AT010268 · NCCIH · BRIGHAM AND WOMEN'S HOSPITAL · PI OH, SUNGWHAN F · 2019 to 2022
$1.8MNCCIH NIH HHS R01 AT010268NCI NIH HHS R01 CA240955NHLBI NIH HHS P01 HL158688NIAID NIH HHS R01 AI116550NIAID NIH HHS R01 AI124491NIAID NIH HHS R01 AI139914NIAID NIH HHS R01 AI167993NIAID NIH HHS R01 AI182369NIAID NIH HHS R37 AI116550NICHD NIH HHS DP1 HD087988NIDDK NIH HHS P30 DK034854
Abstract
Gasdermin D (GSDMD) is the common effector for cytokine secretion and pyroptosis downstream of inflammasome activation and was previously shown to form large transmembrane pores after cleavage by inflammatory caspases to generate the GSDMD N-terminal domain (GSDMD-NT)
Indexed as
GasderminsLipoylationPhosphate-Binding ProteinsReactive Oxygen SpeciesAcyltransferasesAnimalsCryoelectron MicroscopyCysteineFemaleHumansInflammasomesLiposomesMaleMiceMitochondriaPyroptosisAcyltransferasesCysteineGasderminsGSDMD protein, humanGsdmd protein, mouseInflammasomesLiposomesPhosphate-Binding ProteinsReactive Oxygen SpeciesZDHHC5 protein, humanZDHHC9 protein, human
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.