Evidence map›Paper›PMID 38599298›Full record

ArticleBioorganic & medicinal chemistry letters2024

Synthesis and antiproliferative activity of a tetrahydrofuran analog of FR901464.

Ivanna Pohorilets, Jacob P Beard, Julia L Driscoll, John C Schmitz, Kazunori Koide

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ivanna PohoriletsDepartment of Chemistry, University of Pittsburgh 219 Parkman Avenue, Pittsburgh, PA 15260, United States.
Jacob P BeardDepartment of Chemistry, University of Pittsburgh 219 Parkman Avenue, Pittsburgh, PA 15260, United States.
Julia L DriscollDepartment of Chemistry, University of Pittsburgh 219 Parkman Avenue, Pittsburgh, PA 15260, United States.
John C SchmitzDivision of Hematology-Oncology, Department of Medicine, University of Pittsburgh School of Medicine 5150 Centre Avenue, Pittsburgh, PA 15232, United States; Cancer Therapeutics Program, UPMC Hillman Cancer Center 5117 Centre Ave, Pittsburgh, PA 15232, United States.
Kazunori KoideDepartment of Chemistry, University of Pittsburgh 219 Parkman Avenue, Pittsburgh, PA 15260, United States; Cancer Therapeutics Program, UPMC Hillman Cancer Center 5117 Centre Ave, Pittsburgh, PA 15232, United States. Electronic address: koide@pitt.edu.
University of Pittsburgh · US

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHRISTOPHER J. BAKKENIST · 1988 to 2026
$158.0M
NCI NIH HHS P30 CA047904
6 · The paper itself

Abstract

FR901464 is a natural product that exhibits antiproliferative activity at single-digit nanomolar concentrations in cancer cells. Its tetrahydropyran-spiroepoxide covalently binds the spliceosome. Through our medicinal chemistry campaign, we serendipitously discovered that a bromoetherification formed a tetrahydrofuran. The tetrahydrofuran analog was three orders of magnitude less potent than the corresponding tetrahydropyran analogs. This study shows the significance of the tetrahydropyran ring that presents the epoxide toward the spliceosome.

Indexed as

Epoxy CompoundsFuransPyransSpiro CompoundsCell Line, TumorHumansEpoxy CompoundsFR 901464FuransPyransSpiro CompoundsAnticancer activityBromonium ionEpoxideRNA splicingTetrahydrofuran

Identifiers

PMID38599298
PMCPMC11154589
OpenAlexW4394566738

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.