Evidence map›Paper›PMID 38600241›Full record

ArticleThe EMBO journal2024

The Crk4-Cyc4 complex regulates G

Lauren M Hawkins, Chengqi Wang, Dale Chaput, Mrinalini Batra, Clem Marsilia, Danya Awshah, Elena S Suvorova

Open access · diamondAbstract read
In one paragraph

Article in The EMBO journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
9.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Two anchoring proteins control daughter apical complex assembly inbioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Assessing theBio-protocol · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Co-dependent formation of thebioRxiv : the preprint server for biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Lauren M HawkinsDivision of Infectious Diseases, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, 33612, USA.
Chengqi WangCollege of Public Health, University of South Florida, Tampa, FL, 33612, USA.
Dale ChaputProteomics Core, College of Arts and Sciences, University of South Florida, Tampa, FL, 33612, USA.
Mrinalini BatraDivision of Infectious Diseases, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, 33612, USA.
Clem MarsiliaDivision of Infectious Diseases, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, 33612, USA.ORCID http://orcid.org/0009-0007-1273-3665
Danya AwshahDivision of Infectious Diseases, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, 33612, USA.
Elena S SuvorovaDivision of Infectious Diseases, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, 33612, USA. suvorova@usf.edu.ORCID http://orcid.org/0000-0003-4482-8144
University of South Florida · US

Funding

Cyclin-mediated control of Toxoplasma developmentR01AI141467 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI SUVOROVA, ELENA · 2020 to 2024
$1.9M
Regulation of apicomplexan mitosis coupled to buddingR01AI175640 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI Elena Suvorova · 2024 to 2026
$1.6M
Deciphering the composite S-phase in Toxoplasma gondiiR21AI178797 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI SUVOROVA, ELENA · 2023 to 2024
$413k
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI178797NIAID NIH HHS R01 AI141467NIAID NIH HHS R01 AI175640NIAID NIH HHS R21 AI178797
6 · The paper itself

Abstract

A versatile division of apicomplexan parasites and a dearth of conserved regulators have hindered the progress of apicomplexan cell cycle studies. While most apicomplexans divide in a multinuclear fashion, Toxoplasma gondii tachyzoites divide in the traditional binary mode. We previously identified five Toxoplasma CDK-related kinases (Crk). Here, we investigated TgCrk4 and its cyclin partner TgCyc4. We demonstrated that TgCrk4 regulates conventional G

Indexed as

Protozoan ProteinsToxoplasmaCell DivisionCentrosomeCyclinsG2 PhaseCyclinsProtozoan ProteinsApicomplexaCDKCell CycleG2/M CheckpointToxoplasma gondii

Identifiers

PMID38600241
PMCPMC11148040
OpenAlexW4394692940

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.