Evidence map›Paper›PMID 38600368›Full record

ReviewNature reviews. Cardiology2024

Cardiovascular disease and cancer: shared risk factors and mechanisms.

Nicholas S Wilcox, Uri Amit, Jacob B Reibel, Eva Berlin, Kendyl Howell, Bonnie Ky

Abstract readReview
In one paragraph

Review in Nature reviews. Cardiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 176 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
176citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

176 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Effect of combined lifestyle intervention on cardiometabolic risk in cancer survivors: A systematic review and meta-analysis of randomized controlled trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Pooled it
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  13. Dyslipidaemias in cancer patients.European heart journal · 2026
    Review
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116 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nicholas S WilcoxDivision of Cardiology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Uri AmitDepartment of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Jacob B ReibelAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Eva BerlinDepartment of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Kendyl HowellDivision of Cardiology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Bonnie KyDivision of Cardiology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. bonnie.ky@pennmedicine.upenn.edu.ORCID 0000-0002-6628-9981

Funding

CANCER CLINICAL EPIDEMIOLOGY TRAINING GRANTT32CA009679 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Richard Aplenc, Karen Glanz · 1992 to 2026
$11.1M
Mechanistic Risk Prediction of Radiation Therapy CardiotoxicityR01HL148272 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KY, BONNIE · 2020 to 2024
$3.7M
Markers of Cardiotoxicity with Radiation Therapy in Breast CancerR01HL152707 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI BEKELMAN, JUSTIN, KY, BONNIE · 2020 to 2023
$1.6M
MENTORING IN PATIENT-ORIENTED RESEARCH IN DEEP PHENOTYPING IN CARDIO-ONCOLOGYK24HL167127 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Bonnie Ky · 2023 to 2026
$496k
Long Term Effects of Breast Cancer Therapy on Cardiac Remodeling and FunctionR21HL157886 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KY, BONNIE · 2021 to 2022
$447k
NCI NIH HHS T32 CA009679NHLBI NIH HHS K24 HL167127NHLBI NIH HHS R01 HL148272NHLBI NIH HHS R01 HL152707NHLBI NIH HHS R21 HL157886
6 · The paper itself

Abstract

Cardiovascular disease (CVD) and cancer are among the leading causes of morbidity and mortality globally, and these conditions are increasingly recognized to be fundamentally interconnected. In this Review, we present the current epidemiological data for each of the modifiable risk factors shared by the two diseases, including hypertension, hyperlipidaemia, diabetes mellitus, obesity, smoking, diet, physical activity and the social determinants of health. We then review the epidemiological data demonstrating the increased risk of CVD in patients with cancer, as well as the increased risk of cancer in patients with CVD. We also discuss the shared mechanisms implicated in the development of these conditions, highlighting their inherent bidirectional relationship. We conclude with a perspective on future research directions for the field of cardio-oncology to advance the care of patients with CVD and cancer.

Indexed as

Cardiovascular DiseasesNeoplasmsDiabetes MellitusHumansHypertensionObesityRisk AssessmentRisk FactorsSmoking

Identifiers

PMID38600368
PMCPMC11324377

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.