Evidence map›Paper›PMID 38602280›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024

Neuropathologic changes at age 90+ related to sleep duration 19 to 40 years earlier: The 90+ Study.

Zarui A Melikyan, Claudia H Kawas, Annlia Paganini-Hill, Luohua Jiang, Syed Bukhari, Thomas J Montine, Bryce A Mander, María M Corrada

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Sleep fragmentation correlates with amyloid beta deposition at brain autopsy.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  2. Review
  3. Review
  4. Neuropathologic changes at age 90+ related to sleep duration 19 to 40 years earlier: The 90+ Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zarui A MelikyanInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.
Claudia H KawasInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.
Annlia Paganini-HillDepartment of Neurology, University of California, Orange, California, USA.
Luohua JiangDepartment of Epidemiology and Biostatistics, University of California, Irvine, California, USA.
Syed BukhariDepartment of Pathology, Stanford University School of Medicine, Stanford, California, USA.
Thomas J MontineDepartment of Pathology, Stanford University School of Medicine, Stanford, California, USA.
Bryce A ManderInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.
María M CorradaInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.

Funding

Diversity Supplement to R01AG021055; Clinical, Imaging, and Pathological Studies in the Oldest Old: The 90+ StudyR01AG021055 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI CORRADA, MARIA, KAWAS, CLAUDIA H. · 2002 to 2024
$36.9M
Stanford Alzheimer's Disease Research CenterAdmin Supp: Developing iPSC models for AD and PDP30AG066515 · NIA · STANFORD UNIVERSITY · PI Inma Cobos · 2020 to 2026
$29.0M
The Alzheimer's Disease Research Center at the University of California, IrvineP30AG066519 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Mathew Mark Blurton-Jones · 2020 to 2026
$27.9M
Relationships between local and global mechanisms of sleep apnea, Alzheimer's disease biomarkers, and memory impairment in cognitively asymptomatic older adultsK01AG068353 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI MANDER, BRYCE A. · 2020 to 2024
$636k
ESTROGENS AND VITAMIN A ROLE IN DISEASE PREVENTIONR01CA032197 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PAGANINI- HILL, ANNLIA · 1985 to 1991
–
Earl Carrol Trust Fund Los AngelesNCI NIH HHS R01 CA032197NIA NIH HHS K01 AG068353NIA NIH HHS P30 AG066515NIA NIH HHS P30 AG066519NIA NIH HHS R01 AG021055NIH HHS K01AG068353NIH HHS R01AG021055NIH HHS R01CA32197Stanford Alzheimer's Disease Research Center AG066515The Alzheimer's Disease Research Center at the University of California, Irvine AG066519Wyeth-Ayerst Laboratories, Philadelphia 93-022-MA
6 · The paper itself

Abstract

introductionWe investigated the association between sleep duration and neuropathologic changes 19 to 40 years later in oldest-old (age 90+) participants of The 90+ Study.

methodsParticipants self-reported sleep duration and underwent neuropathologic evaluation. We categorized sleep duration as < 7, 7 to 8 = reference, > 8 hours and dichotomized neuropathologic changes as present/absent. We estimated odds ratio (OR) and 95% confidence intervals (CI) using logistic regression.

resultsIn 264 participants, mean age at sleep self-report was 69 years, mean age at autopsy was 98 years, and mean interval between sleep self-report and autopsy was 29 years (range: 19-40). Those reporting > 8 hours of sleep had lower likelihood of limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) inclusions (OR = 0.18; CI = 0.04-0.82) and amyloid beta deposits (OR = 0.34; 95% CI = 0.12-0.94). DISCUSSION: Long self-reported sleep is associated with lower odds of neurodegenerative neuropathologic changes 19 to 40 years later in the oldest-old, suggesting a potential role of sleep in accumulation of dementia-related neuropathologies. HIGHLIGHTS: Association of self-reported sleep with non-Alzheimer's disease neuropathologic changes has not been explored. Whether sleep duration is related to dementia neuropathologic changes decades later is unclear. Long self-reported sleep is associated with lower odds of Alzheimer's disease neuropathologic change 19 to 40 years later in the oldest-old. Long self-reported sleep is associated with lower odds of limbic-predominant age-related TDP-43 encephalopathy neuropathologic change 19 to 40 years later in the oldest-old.

Indexed as

BrainSleepAgedAged, 80 and overAgingAmyloid beta-PeptidesAutopsyFemaleHumansMaleSelf ReportSleep DurationAmyloid beta-Peptidesage 90+neuropathologic changeoldest‐oldself‐reported sleepsleep duration

Identifiers

PMID38602280
PMCPMC11095440

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.