Evidence map›Paper›PMID 38609442›Full record

ArticleScientific reports2024

Biochemical analysis of Hyalomma dromedarii salivary glands and gut tissues using SR-FTIR micro-spectroscopy.

Seham H M Hendawy, Heba F Alzan, Hoda S M Abdel-Ghany, Carlos E Suarez, Gihan Kamel

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 4 countries.

Seham H M HendawyParasitology and Animal Diseases Department, Veterinary Research Institute, National Research Centre, 33 El Buhouth St., Dokki, Giza, 12622, Egypt. seham.hendawy@wsu.edu.
Heba F AlzanParasitology and Animal Diseases Department, Veterinary Research Institute, National Research Centre, 33 El Buhouth St., Dokki, Giza, 12622, Egypt.
Hoda S M Abdel-GhanyParasitology and Animal Diseases Department, Veterinary Research Institute, National Research Centre, 33 El Buhouth St., Dokki, Giza, 12622, Egypt.
Carlos E SuarezDepartment of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA, 99164-7040, USA.
Gihan KamelSESAME Synchrotron (Synchrotron-light for Experimental Science and Applications in the Middle East), Allan, 19252, Jordan. gihan.kamel@sesame.org.jo.
National Research Centre · EGAgricultural Research Service · USHelwan University · EGWashington State University · US

Funding

The Canadian Government and the [Bill and Melinda Gates Foundation] Grant 108525The United States Department of Agriculture (USDA) (ARS-USDA CRIS 2090-32000-039-00-D)The USDA National Institute of Food and Agriculture Proposal Number 2019-05375
6 · The paper itself

Abstract

Ticks are obligatory voracious blood feeders infesting diverse vertebrate hosts, that have a crucial role in the transmission of diverse pathogens that threaten human and animal health. The continuous emergence of tick-borne diseases due to combined worldwide climatic changes, human activities, and acaricide-resistant tick strains, necessitates the development of novel ameliorative tick control strategies such as vaccines. The synchrotron-based Fourier transform infrared micro-spectroscopy (SR-FTIR) is a bioanalytical microprobe capable of exploring the molecular chemistry within microstructures at a cellular or subcellular level and is considered as a nondestructive analytical approach for biological specimens. In this study, SR-FTIR analysis was able to explore a qualitative and semi-quantitative biochemical composition of gut and salivary glands of Hyalomma dromedarii (H. dromedarii) tick detecting differences in the biochemical composition of both tissues. A notable observation regarding Amide I secondary structure protein profile was the higher ratio of aggregated strands in salivary gland and beta turns in gut tissues. Regarding the lipid profile, there was a higher intensity of lipid regions in gut tissue when compared to salivary glands. This detailed information on the biochemical compositions of tick tissues could assist in selecting vaccine and/or control candidates. Altogether, these findings confirmed SR-FTIR spectroscopy as a tool for detecting differences in the biochemical composition of H. dromedarii salivary glands and gut tissues. This approach could potentially be extended to the analysis of other ticks that are vectors of important diseases such as babesiosis and theileriosis.

Indexed as

AcaricidesIxodidaeAnimalsHumansLipidsSalivary GlandsSpectroscopy, Fourier Transform InfraredSynapsinsAcaricidesLipidsSynapsins

Identifiers

PMID38609442
PMCPMC11014997
OpenAlexW4394759502

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.