Evidence map›Paper›PMID 38609527›Full record

ArticleJournal of molecular histology2024

Human neural stem cell secretome relieves endoplasmic reticulum stress-induced apoptosis and improves neuronal functions after traumatic brain injury in a rat model.

Yating Ling, Murugan Ramalingam, Xiaorui Lv, Dongdong Niu, Yu Zeng, Yun Qiu, Yu Si, Tao Guo, Yinying Ni, Jingwen Zhang and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of molecular histology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Mitochondrial-targeted therapies in traumatic brain injury: From bench to bedside.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Yating Ling *Institute of Cerebrovascular Disease, The Affiliated People's Hospital, Jiangsu University, Zhenjiang, China.ORCID http://orcid.org/0000-0002-8324-7070
Murugan Ramalingam *Institute of Tissue Regeneration Engineering, Dankook University, Cheonan, 31116, Republic of Korea.ORCID http://orcid.org/0000-0001-6498-9792
Xiaorui LvInstitute of Cerebrovascular Disease, The Affiliated People's Hospital, Jiangsu University, Zhenjiang, China.
Dongdong NiuInstitute of Cerebrovascular Disease, The Affiliated People's Hospital, Jiangsu University, Zhenjiang, China.
Yu ZengInstitute of Cerebrovascular Disease, The Affiliated People's Hospital, Jiangsu University, Zhenjiang, China.
Yun QiuInstitute of Cerebrovascular Disease, The Affiliated People's Hospital, Jiangsu University, Zhenjiang, China.
Yu SiInstitute of Cerebrovascular Disease, The Affiliated People's Hospital, Jiangsu University, Zhenjiang, China.
Tao GuoInstitute of Cerebrovascular Disease, The Affiliated People's Hospital, Jiangsu University, Zhenjiang, China.
Yinying NiInstitute of Cerebrovascular Disease, The Affiliated People's Hospital, Jiangsu University, Zhenjiang, China.
Jingwen ZhangInstitute of Cerebrovascular Disease, The Affiliated People's Hospital, Jiangsu University, Zhenjiang, China.
Ziyu WangHealth Clinical Laboratories, Health BioMed Co., Ltd. Ningbo, Zhejiang, 315042, China.
Hae-Won KimInstitute of Tissue Regeneration Engineering, Dankook University, Cheonan, 31116, Republic of Korea.
Jiabo HuInstitute of Cerebrovascular Disease, The Affiliated People's Hospital, Jiangsu University, Zhenjiang, China. hu@ujs.edu.cn.ORCID http://orcid.org/0000-0003-1974-984X
Jiangsu University · CNChengdu University · CNHealth Biomed (China) · CN

Funding

he National Natural Science Foundation of China No. 81571221the National Research Foundation of Korea 2018K1A4A3A01064257, 2021R1A5A2022318the Science and Technology Cooperation Foundation of Health Biomed No. 20200605
6 · The paper itself

Abstract

Neural stem cell secretome (NSC-S) plays an important role in neuroprotection and recovery. Studies have shown that endoplasmic reticulum stress (ER stress) is involved in the progression of traumatic brain injury (TBI) and is a crucial cause of secondary damage and neuronal death after brain injury. Whether NSC-S is engaged in ER stress and ER stress-mediated neuronal apoptosis post-TBI has not been investigated. In the study, the Feeney SD male rat model was established. The results showed that NSC-S treatment significantly improved the behavior of rats with TBI. In addition, NSC-S relieved ER stress in TBI rats and was observed by transmission electron microscopy and western blot. The specific mechanism was further elucidated that restoration was achieved by alleviating the PERK-eIF2α pathway and thus protecting neurons from apoptosis. Notably, the discovery of calumenin (CALU) in NSC-S by liquid chromatography-tandem mass spectrometry (LC-MS/MS/MS) may be related to the protective effect of NSC-S on ER stress in neurons. Also, the mechanism by which it functions may be related to ubiquitination. In summary, NSC-S improved prognosis and ER stress in TBI rats and might be a promising treatment for relieving TBI.

Indexed as

ApoptosisBrain Injuries, TraumaticDisease Models, AnimalEndoplasmic Reticulum StressNeural Stem CellsNeuronsRats, Sprague-DawleyAnimalsHumansMaleRatsCalumeninEndoplasmic reticulum stressNeural stem cellsSecretomeTraumatic brain injury

Identifiers

PMID38609527
OpenAlexW4394742354

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.