Evidence map›Paper›PMID 38610019›Full record

ArticleJournal of neuroinflammation2024

Nigrostriatal degeneration determines dynamics of glial inflammatory and phagocytic activity.

Leyre Ayerra, Miguel Angel Abellanas, Leyre Basurco, Ibon Tamayo, Enrique Conde, Adriana Tavira, Amaya Trigo, Clara Vidaurre, Amaia Vilas, Patxi San Martin-Uriz and 5 more

Open access · goldAbstract read
In one paragraph

Article in Journal of neuroinflammation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Leyre Ayerra *Facultad de Ciencias, Departamento de Bioquímica y Genética, Universidad de Navarra, Pamplona, Spain.
Miguel Angel Abellanas *Facultad de Ciencias, Departamento de Bioquímica y Genética, Universidad de Navarra, Pamplona, Spain.
Leyre BasurcoFacultad de Ciencias, Departamento de Bioquímica y Genética, Universidad de Navarra, Pamplona, Spain.
Ibon TamayoCIMA-Universidad de Navarra, Pamplona, España.
Enrique CondeCIMA-Universidad de Navarra, Pamplona, España.
Adriana TaviraFacultad de Ciencias, Departamento de Bioquímica y Genética, Universidad de Navarra, Pamplona, Spain.
Amaya TrigoFacultad de Ciencias, Departamento de Bioquímica y Genética, Universidad de Navarra, Pamplona, Spain.
Clara VidaurreFacultad de Ciencias, Departamento de Bioquímica y Genética, Universidad de Navarra, Pamplona, Spain.
Amaia VilasCIMA-Universidad de Navarra, Pamplona, España.
Patxi San Martin-UrizCIMA-Universidad de Navarra, Pamplona, España.
Esther LuquinFacultad de Medicina, Departamento de Patología, Anatomía y Fisiología, Universidad de Navarra, Pamplona, Spain.
Pedro ClaveroServicio de Neurología, Hospital Universitario de Navarra, Pamplona, Spain.
Elisa MengualFacultad de Medicina, Departamento de Patología, Anatomía y Fisiología, Universidad de Navarra, Pamplona, Spain.
Sandra Hervás-StubbsCIMA-Universidad de Navarra, Pamplona, España.
Maria S AymerichFacultad de Ciencias, Departamento de Bioquímica y Genética, Universidad de Navarra, Pamplona, Spain. maymerich@unav.es.
Universidad de Navarra · ESComplejo Hospitalario de Navarra · ESNavarre Institute of Health Research · ES

Funding

Dirección General de Industria, Energia y Proyectos Estrategicos S3, Gobierno de Navarra PC060-061Instituto de Salud Carlos III PI20/01063Ministerio de Ciencia, Innovación y Universidades FPU19/03255Ministerio de Ciencia, Innovación y Universidades,Spain FPU18/02244Ministerio de Ciencia, Innovación y Universidades,Spain FPU21/01545
6 · The paper itself

Abstract

Glial cells are key players in the initiation of innate immunity in neurodegeneration. Upon damage, they switch their basal activation state and acquire new functions in a context and time-dependent manner. Since modulation of neuroinflammation is becoming an interesting approach for the treatment of neurodegenerative diseases, it is crucial to understand the specific contribution of these cells to the inflammatory reaction and to select experimental models that recapitulate what occurs in the human disease. Previously, we have characterized a region-specific activation pattern of CD11b

Indexed as

NeurogliaNeuroinflammatory DiseasesAnimalsAnti-Inflammatory AgentsAstrocytesDisease Models, AnimalDopamineHumansMicePhagocytesAnti-Inflammatory AgentsDopamineMicrogliaNeurodegenerationParkinson´s diseasePhagocytosis

Identifiers

PMID38610019
PMCPMC11015575
OpenAlexW4394747239

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.