Evidence map›Paper›PMID 38610057›Full record

SynthesisPediatric rheumatology online journal2024

C-reactive protein to albumin ratio as a prognostic tool for predicting intravenous immunoglobulin resistance in children with kawasaki disease: a systematic review of cohort studies.

Jue Liu, Xingguang Chen, Minling Yang, Fangfang Shen, Feng Zhu, Jian Jin, Yiqun Teng

Open access · goldAbstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Pediatric rheumatology online journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Systemic capillary leak syndrome.Nature reviews. Disease primers · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jue LiuDepartment of pediatrics, The Second Affiliated Hospital of Jiaxing University, 314000, Jiaxing, China.
Xingguang ChenDepartment of orthopedics, The Second Affiliated Hospital of Jiaxing University, 314000, Jiaxing, China.
Minling YangDepartment of pediatrics, The Second Affiliated Hospital of Jiaxing University, 314000, Jiaxing, China.
Fangfang ShenDepartment of pediatrics, The Second Affiliated Hospital of Jiaxing University, 314000, Jiaxing, China.
Feng ZhuDepartment of pediatrics, The Second Affiliated Hospital of Jiaxing University, 314000, Jiaxing, China.
Jian Jin *Department of pediatrics, The Second Affiliated Hospital of Jiaxing University, 314000, Jiaxing, China. warswordjj@163.com.
Yiqun Teng *Department of pediatrics, The Second Affiliated Hospital of Jiaxing University, 314000, Jiaxing, China. tengyiqun@zjxu.edu.cn.
Jiaxing University · CN

Funding

Medical Science and Technology Project of Zhejiang Province 2022KY1255Science and Technology Bureau of Jiaxing City 2022AD30123
6 · The paper itself

Abstract

backgroundIntravenous immunoglobulin (IVIG) is the primary treatment for Kawasaki disease (KD). However, 10-20% of KD patients show no response to IVIG treatment, making the early prediction of IVIG resistance a key focus of KD research. Our aim is to explore the application of the C-reactive protein to albumin ratio (CAR) for predicting IVIG resistance in children with KD through meta-analysis.

methodsCochrane Library, PubMed, MEDLINE, EMbase, CNKI, WanFang, the Chinese Biomedical Database, and CQVIP were searched up to November 2023 for cohort studies on predicting IVIG-resistant KD using the CAR. Articles were selected based on pre-established inclusion and exclusion criteria after extracting literature data and assessing them using the QUADAS-2.0 tool for evaluating the accuracy of diagnostic tests. Stata 15.0 software was used for meta-analysis.

resultsFour Chinese and English literature reports were included in this meta-analysis. The results revealed the presence of a threshold effect and high heterogeneity among the included studies. The combined sensitivity for CAR predicting IVIG-resistant KD was calculated as 0.65 (95% CI 0.58-0.72), specificity as 0.71 (95% CI 0.57-0.81), and the area under the curve (AUC) as 0.70 (95% CI 0.66-0.74) using the random-effects model. The combined positive likelihood ratio was 2.22 (95% CI 1.35-3.65), the combined negative likelihood ratio was 0.49 (95% CI 0.35-0.69), and the diagnostic odds ratio was 5 (95% CI 2-10).

conclusionCAR is an auxiliary predictive indicator with moderate diagnostic value that provides guidance in the early treatment of the disease, demonstrating a certain predictive value that warrants further investigation. However, CAR cannot yet be considered as a definitive diagnostic or exclusionary marker for IVIG-resistant KD. Therefore, multi-center, large sample, and high-quality long-term follow-up trials are warranted to confirm the current findings.

Indexed as

C-Reactive ProteinMucocutaneous Lymph Node SyndromeAlbuminsChildCohort StudiesHumansImmunoglobulins, IntravenousPrognosisAlbuminsC-Reactive ProteinImmunoglobulins, IntravenousC-reactive protein to albumin ratioIntravenous immunoglobulin resistanceKawasaki Diseasemeta-analysisPrediction

Identifiers

PMID38610057
PMCPMC11010335
OpenAlexW4394765359

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.