Evidence map›Paper›PMID 38611900›Full record

ArticleMolecules (Basel, Switzerland)2024

New Charged Cholinesterase Inhibitors: Design, Synthesis, and Characterization.

Milena Mlakić, Danijela Barić, Ana Ratković, Ivana Šagud, Ivona Čipor, Ivo Piantanida, Ilijana Odak, Irena Škorić

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Milena MlakićDepartment of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Trg Marka Marulića 19, HR-10 000 Zagreb, Croatia.
Danijela BarićGroup for Computational Life Sciences, Division of Physical Chemistry, Ruđer Bošković Institute, Bijenička Cesta 54, HR-10 000 Zagreb, Croatia.ORCID 0000-0002-5614-5167
Ana RatkovićChemistry, Selvita Ltd., Prilaz Baruna Filipovića 29, HR-10 000 Zagreb, Croatia.
Ivana ŠagudCroatian Agency for Medicinal Products and Medical Devices, Ksaverska Cesta 4, HR-10 000 Zagreb, Croatia.ORCID 0000-0003-4410-3602
Ivona ČiporDivision of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička Cesta 54, HR-10 000 Zagreb, Croatia.ORCID 0009-0004-1512-4089
Ivo PiantanidaDivision of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička Cesta 54, HR-10 000 Zagreb, Croatia.ORCID 0000-0002-9933-446X
Ilijana OdakDepartment of Chemistry, Faculty of Science and Education, University of Mostar, Matice Hrvatske bb, 88000 Mostar, Bosnia and Herzegovina.ORCID 0000-0002-6883-8470
Irena ŠkorićDepartment of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Trg Marka Marulića 19, HR-10 000 Zagreb, Croatia.ORCID 0000-0002-1563-7261
Ruđer Bošković Institute · HRUniversity of Zagreb · HRAgency for Medicinal Products and Medical Devices of Croatia · HRPliva (Croatia) · HRUniversity of Mostar · BA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Triazoles and triazolium salts are very common subunits in the structures of various drugs. Medicaments with a characteristic 1,2,3-triazole core are also being developed to treat neurodegenerative disorders associated with cholinesterase enzyme activity. Several naphtho- and thienobenzo-triazoles from our previous research emerged as being particularly promising in that sense. For this reason, in this research, new naphtho- and thienobenzo-triazoles

Indexed as

ButyrylcholinesteraseCholinesterase InhibitorsAcetylcholinesteraseMolecular Docking SimulationMultienzyme ComplexesSaltsTriazolesAcetylcholinesteraseButyrylcholinesteraseCholinesterase InhibitorsMultienzyme ComplexesSaltsTriazolesAChEBChEcholinesterase inhibitorsdockinggenotoxicitysynthesistriazolestriazolium salts

Identifiers

PMID38611900
PMCPMC11013433
OpenAlexW4393935490

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.