More than Just Bread and Wine: Using Yeast to Understand Inherited Cytochrome Oxidase Deficiencies in Humans.

Chenelle A Caron-Godon, Emma Collington, Jessica L Wolf, Genna Coletta, D Moira Glerum

Open access · goldAbstract readReview

In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it

0cells of the map it votes in

4citing papers in PubMed

1.2field-weighted citation impact, top 23% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

6PPD and 6PPD-Q Induce Mitochondrial Dysfunction inInternational journal of molecular sciences · 2026
Article
Transcriptomics combined with metabolomics to elucidate the mechanisms of bacterial otitis media infection: insights from mitochondrial dysfunction.BMC microbiology · 2026
Article
Integration of human ERKs and DUSPs into the yeast cell wall integrity pathway.Scientific reports · 2025
Article
Heart is the most susceptible organ in an isogenic background to loss of function mutations in the mitochondrial metallochaperone SCO1.Human molecular genetics · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Chenelle A Caron-GodonDepartment of Biology, University of Waterloo, Waterloo, ON N2L 3G1, Canada.ORCID 0009-0004-1115-1709

Emma CollingtonDepartment of Biology, University of Waterloo, Waterloo, ON N2L 3G1, Canada.ORCID 0000-0002-6507-8955

Jessica L WolfDepartment of Biology, University of Waterloo, Waterloo, ON N2L 3G1, Canada.ORCID 0009-0000-7767-1847

Genna ColettaDepartment of Biology, University of Waterloo, Waterloo, ON N2L 3G1, Canada.

D Moira GlerumDepartment of Biology, University of Waterloo, Waterloo, ON N2L 3G1, Canada.ORCID 0000-0002-2307-0568

University of Waterloo · CA

Funding

Natural Sciences and Engineering Research Council RGPIN 227415

6 · The paper itself

Abstract

Inherited defects in cytochrome

Indexed as

Cytochrome-c Oxidase DeficiencyWineBreadElectron Transport Complex IVHumansSaccharomyces cerevisiaeElectron Transport Complex IVcopper transferCOX assemblyheme A biosynthesismitochondrial diseaseyeast model

Identifiers

PMID38612624

DOI10.3390/ijms25073814

PMCPMC11011759

OpenAlexW4393309688

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.