Evidence map›Paper›PMID 38612653›Full record

ArticleInternational journal of molecular sciences2024

A Stem-like Patient-Derived Ovarian Cancer Model of Platinum Resistance Reveals Dissociation of Stemness and Resistance.

Tise Suzuki, Ashlyn Conant, Yeonkyu Jung, Ryan Bax, Ashley Antonissen, Wanqiu Chen, Gary Yu, Yevgeniya J Ioffe, Charles Wang, Juli J Unternaehrer

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
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  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Tise SuzukiDivision of Biochemistry, Department of Basic Sciences, Loma Linda University, Loma Linda, CA 92354, USA.
Ashlyn ConantDivision of Biochemistry, Department of Basic Sciences, Loma Linda University, Loma Linda, CA 92354, USA.
Yeonkyu JungDivision of Biochemistry, Department of Basic Sciences, Loma Linda University, Loma Linda, CA 92354, USA.
Ryan BaxDivision of Biochemistry, Department of Basic Sciences, Loma Linda University, Loma Linda, CA 92354, USA.
Ashley AntonissenDivision of Biochemistry, Department of Basic Sciences, Loma Linda University, Loma Linda, CA 92354, USA.
Wanqiu ChenDivision of Biochemistry, Department of Basic Sciences, Loma Linda University, Loma Linda, CA 92354, USA.
Gary YuDepartment of Population and Family Health, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
Yevgeniya J IoffeDivision of Gynecologic Oncology, Department of Gynecology and Obstetrics, Loma Linda University Medical Center, Loma Linda, CA 92354, USA.
Charles WangDivision of Biochemistry, Department of Basic Sciences, Loma Linda University, Loma Linda, CA 92354, USA.ORCID 0000-0001-8861-2121
Juli J UnternaehrerDivision of Biochemistry, Department of Basic Sciences, Loma Linda University, Loma Linda, CA 92354, USA.ORCID 0000-0001-5864-4704
Loma Linda University · USLoma Linda University Medical Center · USColumbia University · US

Funding

Loma Linda University 2210400
6 · The paper itself

Abstract

To understand chemoresistance in the context of cancer stem cells (CSC), a cisplatin resistance model was developed using a high-grade serous ovarian cancer patient-derived, cisplatin-sensitive sample, PDX4. As a molecular subtype-specific stem-like cell line, PDX4 was selected for its representative features, including its histopathological and

Indexed as

Ovarian NeoplasmsPlatinumCarcinoma, Ovarian EpithelialCisplatinFemaleHumansCisplatinPlatinumcancer stemnesscisplatin resistanceepithelial–mesenchymal transitionhigh-grade serous ovarian cancerpatient-derived modelRNA sequencing

Identifiers

PMID38612653
PMCPMC11011340
OpenAlexW4393356592

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.