Evidence map›Paper›PMID 38613458›Full record

ArticleACS chemical neuroscience2024

Catharanthine Modulates Mesolimbic Dopamine Transmission and Nicotine Psychomotor Effects via Inhibition of α6-Nicotinic Receptors and Dopamine Transporters.

Benjamin M Williams, Nathan D Steed, Joel T Woolley, Aubrey A Moedl, Christina A Nelson, Gavin C Jones, Matthew D Burris, Hugo R Arias, Oc-Hee Kim, Eun Young Jang and 4 more

Open access · hybridAbstract read
In one paragraph

Article in ACS chemical neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Benjamin M WilliamsDepartment of Psychology/Neuroscience, Brigham Young University, Provo, Utah 84602, United States.
Nathan D SteedDepartment of Psychology/Neuroscience, Brigham Young University, Provo, Utah 84602, United States.
Joel T WoolleyDepartment of Psychology/Neuroscience, Brigham Young University, Provo, Utah 84602, United States.
Aubrey A MoedlDepartment of Psychology/Neuroscience, Brigham Young University, Provo, Utah 84602, United States.
Christina A NelsonDepartment of Psychology/Neuroscience, Brigham Young University, Provo, Utah 84602, United States.
Gavin C JonesDepartment of Psychology/Neuroscience, Brigham Young University, Provo, Utah 84602, United States.ORCID 0000-0002-6294-5355
Matthew D BurrisDepartment of Psychology/Neuroscience, Brigham Young University, Provo, Utah 84602, United States.
Hugo R AriasDepartment of Pharmacology and Physiology, Oklahoma State University College of Osteopathic Medicine, Tahlequah, Oklahoma 74464, United States.
Oc-Hee KimDepartment of Advanced Toxicology Research, Korea Institute of Toxicology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, Korea.
Eun Young JangDepartment of Advanced Toxicology Research, Korea Institute of Toxicology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, Korea.
Arik J HoneGeorge E. Wahlen Veterans Affairs Medical Center, and Departments of Psychiatry and Biology, University of Utah, Salt Lake City, Utah 84112, United States.ORCID 0000-0002-9912-0955
J Michael McIntoshGeorge E. Wahlen Veterans Affairs Medical Center, and Departments of Psychiatry and Biology, University of Utah, Salt Lake City, Utah 84112, United States.
Jordan T YorgasonDepartment of Psychology/Neuroscience, Brigham Young University, Provo, Utah 84602, United States.ORCID 0000-0002-5687-0676
Scott C SteffensenDepartment of Psychology/Neuroscience, Brigham Young University, Provo, Utah 84602, United States.ORCID 0000-0001-6463-8861
Brigham Young University · USKorea Institute of Toxicology · KRUniversity of Utah · USOklahoma State University Medical Center · US

Funding

Development and Application of Nicotinic Acetylcholine Receptor Targeted Peptides for Biomedical ResearchR35GM136430 · NIGMS · UNIVERSITY OF UTAH · PI MCINTOSH, J MICHAEL · 2020 to 2024
$2.3M
Nicotine and Alcohol Co-DependenceR01DA035958 · NIDA · BRIGHAM YOUNG UNIVERSITY · PI STEFFENSEN, SCOTT C · 2014 to 2018
$2.0M
Neuroplasticity with alcohol dependenceR01AA020919 · NIAAA · BRIGHAM YOUNG UNIVERSITY · PI STEFFENSEN, SCOTT C · 2012 to 2016
$1.5M
Neuroimmune mechanisms of alcohol rewardR01AA030577 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Jordan Thomas Yorgason · 2023 to 2026
$1.3M
NIAAA NIH HHS R01 AA020919NIAAA NIH HHS R01 AA030577NIDA NIH HHS R01 DA035958NIGMS NIH HHS R35 GM136430
6 · The paper itself

Abstract

Iboga alkaloids, also known as coronaridine congeners, have shown promise in the treatment of alcohol and opioid use disorders. The objective of this study was to evaluate the effects of catharanthine and 18-methoxycoronaridine (18-MC) on dopamine (DA) transmission and cholinergic interneurons in the mesolimbic DA system, nicotine-induced locomotor activity, and nicotine-taking behavior. Utilizing

Indexed as

DopamineDopamine Plasma Membrane Transport ProteinsIbogaineNicotineReceptors, NicotinicAnimalsDose-Response Relationship, DrugInterneuronsMaleMiceMice, Inbred C57BLMotor ActivityNicotinic AgonistsNicotinic AntagonistsNucleus AccumbensOocytes18-methoxycoronaridineDopamineDopamine Plasma Membrane Transport ProteinsIbogaineNicotineNicotinic AgonistsNicotinic Antagonistsnicotinic receptor alpha6Receptors, Nicotinic18-methoxycoronaridineaddictioncatharanthinedopamineNicotinenicotinic acetylcholine receptorsnucleus accumbens coreself-administrationvoltammetry

Identifiers

PMID38613458
PMCPMC11744774
OpenAlexW4394786695

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.