Evidence map›Paper›PMID 38613621›Full record

ReviewCurrent hypertension reports2024

Neuroimmunology of Cardiovascular Disease.

Sara M Zarate, Annet Kirabo, Antentor O Hinton, Monica M Santisteban

Open access · hybridAbstract readReview
In one paragraph

Review in Current hypertension reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Neuroimmune interactions in cardiovascular homeostasis and disease.American journal of physiology. Cell physiology · 2026
    Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Immune Mechanisms in Hypertension.Hypertension (Dallas, Tex. : 1979) · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Sara M ZarateDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, USA.
Annet KiraboDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, USA.
Antentor O HintonDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, USA.
Monica M SantistebanDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, USA. monica.santisteban@vumc.org.
Biology of Infection · FRVanderbilt Health · USVanderbilt University · USVanderbilt University Medical Center · US

Funding

Enhancing parasympathetic activity to reduce vascular oxidative stress and endothelial dysfunctionR01HL157584 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KIRABO, ANNET, SHIBAO, CYNDYA ADRIANA · 2021 to 2024
$3.0M
Immune Mechanisms of Salt-Sensitive hypertensionR01HL144941 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KIRABO, ANNET · 2021 to 2025
$3.0M
Salt Mediated Cross Talk Between Lymphatic Vessels and Immune Cells in Kidney DiseaseR01DK135764 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI VALENTINA KON, Annet Kirabo · 2023 to 2026
$2.9M
Vanderbilt Hypertension and Blood Pressure Regulation ProgramT32HL144446 · NHLBI · VANDERBILT UNIVERSITY · PI HARRISON, DAVID G · 2019 to 2023
$1.7M
Neuroimmune Mechanisms of Cognitive Impairment in Salt-sensitive HypertensionK22NS123507 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI SANTISTEBAN FREEMAN, MONICA M · 2021 to 2025
$982k
American Heart Association 23SCEFIA1155595Burroughs Wellcome Fund Career Award at the Scientific InterfaceChan Zuckerberg Initiative Science Diversity Leadership Grant 2022-253529NHLBI NIH HHS R01 HL144941NHLBI NIH HHS R01 HL157584NIDDK NIH HHS R01 DK135764NIH HHS K22NS123507NIH HHS R01HL144941, R01HL157584, R01DK135764, R21TW012635NIH HHS T32HL144446NINDS NIH HHS K22 NS123507
6 · The paper itself

Abstract

purpose of reviewCardiovascular disease (CVD) is a leading cause of death and chronic disability worldwide. Yet, despite extensive intervention strategies the number of persons affected by CVD continues to rise. Thus, there is great interest in unveiling novel mechanisms that may lead to new treatments. Considering this dilemma, recent focus has turned to the neuroimmune mechanisms involved in CVD pathology leading to a deeper understanding of the brain's involvement in disease pathology. This review provides an overview of new and salient findings regarding the neuroimmune mechanisms that contribute to CVD. RECENT

findingsThe brain contains neuroimmune niches comprised of glia in the parenchyma and immune cells at the brain's borders, and there is strong evidence that these neuroimmune niches are important in both health and disease. Mechanistic studies suggest that the activation of glia and immune cells in these niches modulates CVD progression in hypertension and heart failure and contributes to the inevitable end-organ damage to the brain. This review provides evidence supporting the role of neuroimmune niches in CVD progression. However, additional research is needed to understand the effects of prolonged neuroimmune activation on brain function.

Indexed as

BrainCardiovascular DiseasesNeuroimmunomodulationAnimalsHumansNeurogliaBorder associated immune cellsCardiovascular diseaseHypertensionNeuroimmunologyNeuroinflammation

Identifiers

PMID38613621
PMCPMC11199253
OpenAlexW4394786193

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.