Evidence map›Paper›PMID 38613713›Full record

ArticleJournal of fluorescence2025

Synthesis and Characterization of Zn(II) Complex of 4-chloro-2-(((2-phenoxyphenyl)imino)methyl)phenol and its Biological Efficacies: DNA Interaction, ADMET, DFT and Molecular Docking Study.

Uttam Kumar Singha, Sudarshan Pradhan, Pritika Gurung, Prajal Chhetri, Anmol Chettri, Tanmoy Dutta, Biswajit Sinha

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Article in Journal of fluorescence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Uttam Kumar SinghaDepartment of Chemistry, University of North Bengal, Darjeeling, 734013, India.
Sudarshan PradhanDepartment of Chemistry, University of North Bengal, Darjeeling, 734013, India.
Pritika GurungDepartment of Chemistry, University of North Bengal, Darjeeling, 734013, India.
Prajal ChhetriDepartment of Chemistry, University of North Bengal, Darjeeling, 734013, India.
Anmol ChettriDepartment of Chemistry, University of North Bengal, Darjeeling, 734013, India.
Tanmoy DuttaDepartment of Chemistry, JIS College of Engineering, Kalyani, 741235, India.
Biswajit SinhaDepartment of Chemistry, University of North Bengal, Darjeeling, 734013, India. biswachem@gmail.com.
North Bengal University · INUniversity of Kalyani · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Condensing 2-phenoxyaniline with 5-chlorosalicyldehyde under reflux conditions, a 4-chloro-2-(((2-phenoxyphenyl)imino)methyl)phenol Schiff base has been Synthesized. A zinc complex was synthesized by combining the ligand in a 1:1 molar ratio with zinc sulphateheptahydrate. Mass spectroscopy, NMR, infrared, and elemental analysis were used to characterize the ligand and zinc complex. By measuring the molar conductance, the non-electrolytic character of the complex was confirmed. The zinc ion is coordinated in a pentadentate manner, according to an IR and NMR investigation. Viscosity measurements, absorption and fluorescence spectroscopy were utilized to examine the complex's interaction with CT (calf thymus) DNA. Furthermore, the ligand and complex's ADMET characteristics were ascertained through the use of ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) study. Calculation of the different electronic parameters of the optimized structure through Density Functional Theory (DFT) indicated the stability of the Zn(II) complex. Molecular docking study reflected the future opportunity for the consideration of Zn(II) complex to fight against Alzheimer and Glaucoma diseases.

Indexed as

Coordination ComplexesDensity Functional TheoryDNAMolecular Docking SimulationPhenolsZincAnimalsCattleMolecular StructureSchiff Basescalf thymus DNACoordination ComplexesDNAPhenolsSchiff BasesZincADMET propertiesDFTDNA interactionMolecular dockingSchiff baseZn(II) complex

Identifiers

PMID38613713
OpenAlexW4394786148

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.