Evidence map›Paper›PMID 38614102›Full record

ArticleNeuron2024

Prefrontal cortical dynorphin peptidergic transmission constrains threat-driven behavioral and network states.

Huikun Wang, Rodolfo J Flores, Hector E Yarur, Aaron Limoges, Hector Bravo-Rivera, Sanne M Casello, Niharika Loomba, Juan Enriquez-Traba, Miguel Arenivar, Queenie Wang and 10 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 1 country.

Huikun WangNeuromodulation and Synaptic Integration Unit, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.
Rodolfo J FloresNeuromodulation and Synaptic Integration Unit, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.
Hector E YarurNeuromodulation and Synaptic Integration Unit, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.
Aaron LimogesNeuromodulation and Synaptic Integration Unit, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA; Columbia University - NIH Graduate Partnership Program, National Institutes of Health, Bethesda, MD, USA.
Hector Bravo-RiveraNeuromodulation and Synaptic Integration Unit, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.
Sanne M CaselloNeuromodulation and Synaptic Integration Unit, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.
Niharika LoombaNeuromodulation and Synaptic Integration Unit, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.
Juan Enriquez-TrabaNeuromodulation and Synaptic Integration Unit, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.
Miguel ArenivarNeuromodulation and Synaptic Integration Unit, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA; Brown University - NIH Graduate Partnership Program, National Institutes of Health, Bethesda, MD, USA.
Queenie WangNeuromodulation and Synaptic Integration Unit, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.
Robert GanleyMolecular Genetics Section, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
Charu RamakrishnanDepartments of Bioengineering and Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Lief E FennoDepartments of Bioengineering and Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Yoon KimDepartments of Bioengineering and Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Karl DeisserothDepartments of Bioengineering and Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Grace OrDepartment of Biochemistry and Molecular Medicine, University of California, Davis, Davis, CA, USA.
Chunyang DongDepartment of Biochemistry and Molecular Medicine, University of California, Davis, Davis, CA, USA.
Mark A HoonMolecular Genetics Section, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
Lin TianDepartment of Biochemistry and Molecular Medicine, University of California, Davis, Davis, CA, USA; Max Planck Florida Institute for Neuroscience, Jupiter, FL, USA.
Hugo A TejedaNeuromodulation and Synaptic Integration Unit, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA. Electronic address: hugo.tejeda@nih.gov.
National Institutes of Health · USStanford University · USUniversity of California, Davis · USMax Planck Florida Institute for Neuroscience · US

Funding

Unit of Neuromodulation and Synaptic IntegrationZIAMH002970 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI TEJEDA, HUGO · 2019 to 2025
$11.1M
Intramural NIH HHS ZIA MH002970
6 · The paper itself

Abstract

Prefrontal cortical (PFC) circuits provide top-down control of threat reactivity. This includes ventromedial PFC (vmPFC) circuitry, which plays a role in suppressing fear-related behavioral states. Dynorphin (Dyn) has been implicated in mediating negative affect and maladaptive behaviors induced by severe threats and is expressed in limbic circuits, including the vmPFC. However, there is a critical knowledge gap in our understanding of how vmPFC Dyn-expressing neurons and Dyn transmission detect threats and regulate expression of defensive behaviors. Here, we demonstrate that Dyn cells are broadly activated by threats and release Dyn locally in the vmPFC to limit passive defensive behaviors. We further demonstrate that vmPFC Dyn-mediated signaling promotes a switch of vmPFC networks to a fear-related state. In conclusion, we reveal a previously unknown role of vmPFC Dyn neurons and Dyn neuropeptidergic transmission in suppressing defensive behaviors in response to threats via state-driven changes in vmPFC networks.

Indexed as

DynorphinsFearNeuronsPrefrontal CortexAnimalsBehavior, AnimalMaleMiceMice, Inbred C57BLNerve NetDynorphinsconditioningdynorphingenetically encoded neuromodulator sensorkappa opioid receptorneural circuit dynamicsprefrontal cortexthreats

Identifiers

PMID38614102
PMCPMC11250624
OpenAlexW4394748951

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.