Evidence map›Paper›PMID 38616987›Full record

ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2024

Semaglutide Effects on Metabolic Outcomes in Diabetes Mellitus Patients - Real World Study.

Carlos Mario Balcázar-Valencia, Andrés Felipe García-Ramos, Luis Miguel Osorio-Toro, Yessica Alejandra Ordoñez-Guzmán, Nathalia Buitrago-Gómez, William Fernando Cabarcas-López, Carlos Javier Vizcaino-Guerrero, Jorge Enrique Daza-Arana, Alex Ramírez-Rincón, Katherine Restrepo-Erazo

Open access · goldAbstract read
In one paragraph

Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 1 country.

Carlos Mario Balcázar-ValenciaSpecialization in Internal Medicine, Faculty of Health Sciences, Universidad Libre, Santiago de Cali, Colombia.ORCID 0000-0001-9083-4460
Andrés Felipe García-RamosSpecialization in Internal Medicine, Faculty of Health, Universidad Santiago de Cali, Santiago de Cali, Colombia.ORCID 0000-0003-4358-3894
Luis Miguel Osorio-ToroSpecialization in Internal Medicine, Faculty of Health, Universidad Santiago de Cali, Santiago de Cali, Colombia.ORCID 0000-0002-1971-6354
Yessica Alejandra Ordoñez-GuzmánResearch and Education Department, Clínica de Occidente S.A., Santiago de Cali, Colombia.ORCID 0009-0001-6659-0010
Nathalia Buitrago-GómezSpecialization in Endocrinology, Faculty of Health Sciences, Universidad Pontificia Bolivariana, Medellín, Colombia.ORCID 0000-0001-7466-9645
William Fernando Cabarcas-LópezMaster in Epidemiology, Faculty of Health, Universidad de Caldas, Manizales, Colombia.ORCID 0000-0002-9533-6791
Carlos Javier Vizcaino-GuerreroSpecialization in Endocrinology, Faculty of Health, Fundación Universitaria Ciencias de la Salud FUCS, Bogotá, Colombia.
Jorge Enrique Daza-AranaSpecialization in Internal Medicine, Faculty of Health, Universidad Santiago de Cali, Santiago de Cali, Colombia.ORCID 0000-0002-4936-1507
Alex Ramírez-RincónSpecialization in Endocrinology, Faculty of Health Sciences, Universidad Pontificia Bolivariana, Medellín, Colombia.ORCID 0000-0002-3925-6201
Katherine Restrepo-ErazoSpecialization in Internal Medicine, Faculty of Health, Universidad Santiago de Cali, Santiago de Cali, Colombia.ORCID 0009-0002-6066-2180
Universidad Pontificia Bolivariana · COUniversidad Santiago de Cali · COFundación Universitaria de Ciencias de la Salud · COUniversidad Autónoma de Occidente · COUniversidad Libre de Colombia · COUniversidad Nacional de Colombia · COUniversity of Caldas · CO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Diabetes is a public health problem that requires strategies to impact glycemic control and reduce the risk of long-term medical complications. Pharmacological management is a necessary treatment for this disease. Therefore, semaglutide is an essential tool to achieve the treatment targets. The present study aimed to evaluate the semaglutide effects on a cohort with type 2 diabetes mellitus (T2DM) in Colombia. Materials and Methods: The cohort included 49 patients with T2DM that have been treated in a specialized care center. Their glycemic outcomes, weight, renal function, and adverse events were evaluated through a 3-, 6- and 12-month follow-up. Results: Significant differences were observed in the outcome evaluation: reduction of glycated hemoglobin levels (MD -2.74 CI -1.95 to -3.52 in 6 months), fasting plasma glucose levels, body weight (MD -7.11 CI -5.97 to -8.24), and the albumin-to-creatinine ratio. The results were maintained throughout the treatment period. The adverse event rate was 16.3%, predominating gastrointestinal events. Conclusion: This real-world evidence shows the efficacy of semaglutide in achieving treatment goals in patients with T2DM.

Indexed as

diabetes mellitusglycated hemoglobin Aglycemic controlobesitysemaglutide

Identifiers

PMID38616987
PMCPMC11016261
OpenAlexW4394690564

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.