Evidence map›Paper›PMID 38617114›Full record

ArticleAlzheimer's & dementia (New York, N. Y.)

Sex differences in Alzheimer's disease blood biomarkers in a Caribbean population of African ancestry: The Tobago Health Study.

Caterina Rosano, Thomas K Karikari, Ryan Cvejkus, Bruna Bellaver, Pamela C L Ferreira, Joseph Zmuda, Victor Wheeler, Tharick A Pascoal, Iva Miljkovic

Open access · goldAbstract read
In one paragraph

Article in Alzheimer's & dementia (New York, N. Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Reproductive health history and later life cognition in African Caribbean women.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 3 countries.

Caterina RosanoDepartment of Epidemiology School of Public Health University of Pittsburgh Pittsburgh Pennsylvania USA.ORCID https://orcid.org/0000-0002-0909-1506
Thomas K KarikariDepartment of Psychiatry University of Pittsburgh Pittsburgh Pennsylvania USA.
Ryan CvejkusDepartment of Epidemiology School of Public Health University of Pittsburgh Pittsburgh Pennsylvania USA.
Bruna BellaverDepartment of Psychiatry University of Pittsburgh Pittsburgh Pennsylvania USA.
Pamela C L FerreiraDepartment of Psychiatry University of Pittsburgh Pittsburgh Pennsylvania USA.
Joseph ZmudaDepartment of Epidemiology School of Public Health University of Pittsburgh Pittsburgh Pennsylvania USA.
Victor WheelerTobago Health Studies Office Scarborough Tobago Trinidad and Tobago.
Tharick A PascoalDepartment of Neurology School of Medicine University of Pittsburgh Pittsburgh Pennsylvania USA.
Iva MiljkovicDepartment of Epidemiology School of Public Health University of Pittsburgh Pittsburgh Pennsylvania USA.
University of Pittsburgh · USUniversity of Trinidad and Tobago · TT

Funding

Plasma brain-derived tau: a novel Alzheimer’s disease-type neurodegeneration biomarker with potential to complete the AT(N) scheme in bloodR01AG083874 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Thomas K Karikari · 2023 to 2026
$14.5M
Epidemiology of Bone Loss in African MenR01AR049747 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZMUDA, JOSEPH M. · 2003 to 2014
$5.9M
Myosteatosis, Cognition, and Blood Biomarkers of Alzheimer's Disease in Persons of African AncestryRF1AG077474 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MILJKOVIC, IVA, ROSANO, CATERINA · 2022 to 2024
$3.6M
Epidemiology of Obesity, Diabetes, and Hypertension in African CaribbeansR01HL143793 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MILJKOVIC, IVA · 2018 to 2021
$2.7M
Population Neuroscience of Aging and Alzheimer's Disease (PNA)T32AG055381 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Caterina Rosano, Andrea L Rosso · 2018 to 2026
$2.7M
Ectopic adiposity in black men with high type 2 diabetes riskR01DK097084 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MILJKOVIC, IVA · 2013 to 2016
$1.9M
Determinants of Bone Strength in Afro-Caribbean FamiliesR03AR050107 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZMUDA, JOSEPH M · 2003 to 2004
$149k
NHLBI NIH HHS R01 HL143793NIAMS NIH HHS R01 AR049747NIAMS NIH HHS R03 AR050107NIA NIH HHS R01 AG083874NIA NIH HHS RF1 AG077474NIA NIH HHS T32 AG055381NIDDK NIH HHS R01 DK097084
6 · The paper itself

Abstract

introductionAlzheimer's disease (AD) is increasing in the Caribbean, especially for persons of African ancestry (PAA) and women. However, studies have mostly utilized surveys without AD biomarkers.

methodsIn the Tobago Health Study (

resultsWomen were more obese, hypertensive, and sedentary but reported less smoking and alcohol use than men (age-adjusted DISCUSSION: Women had worse AD biomarkers than men, unexplained by age, cardiometabolic diseases, or lifestyle. Studying risk factors for AD in PAA is warranted, especially for women earlier in life.

Indexed as

ADRDAfrican Ancestryblood biomarkers of Alzheimer's Pathologycardiometabolic diseasesCaribbeanearly and late life exposureglobal dementia epidemicunderserved

Identifiers

PMID38617114
PMCPMC11010267
OpenAlexW4394752038

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.