ReviewHaematologica2024
Oral iron supplementation: new formulations, old questions.
Review in Haematologica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06942208 (Iron Revisited), which is not on this map. Cited by 59 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Iron Revisited: Alternate-Day Oral Iron Supplementation in Endurance, Intermittent, and Power/Strength Athletes
Who cites it
59 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Preclinical perspectives on common iron fortificants and their bioavailability in rat models: a systematic review and meta-analysis.Frontiers in public health · 2026Pooled it
- Economic evaluation of intravenous iron formulations for patients with iron deficiency anemia: a systematic review.Frontiers in health services · 2025Pooled it
- Preoperative iron supplementation in non-anemic patients undergoing major surgery: a systematic review and meta-analysis.Brazilian journal of anesthesiology (Elsevier)Pooled it
- Evaluating the Role of School-Based Weekly Iron-Folic Acid Supplementation in Shaping Common Morbidity and Growth Outcomes Among Adolescent Girls: Evidence From a Cluster-Randomized Controlled Trial in Central Ethiopia Region.Maternal & child nutrition · 2026Trial
- Oral liposomal iron vs. oral iron polymaltose in children with chronic kidney disease iron deficiency anemia: a cross-over study.Pediatric nephrology (Berlin, Germany) · 2026Trial
- Energy restriction and iron supplementation improve iron status in women with obesity regardless of red meat consumption: a randomized controlled trial.Scientific reports · 2026Trial
- Effect of food on iron absorption in patients with iron deficiency anemia treated with ferric citrate hydrate.International journal of hematology · 2026Trial
- A Randomized, Open-Label, Single-Dose, Parallel-Group Bioequivalence Study of Ferric Carboxymaltose Injection Under Fasting Conditions in Chinese Adult Subjects With Iron Deficiency Anemia.Pharmacology research & perspectives · 2025Trial
- Trial
- Nano-enabled strategies for iron deficiency and iron deficiency anemia: iron-based nanoparticles for supplementation, bioavailability, and food fortification-a narrative review.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Review
- Increasing utilisation of intravenous iron among Australian women of reproductive age, 2013-2024: an Australian population-based study.Internal medicine journal · 2026Observational
- Inherited microcytic anemias due to disorders of iron and heme metabolism: An updated clinical review.HemaSphere · 2026Review
- Ferritin as a diagnostic point-of-care marker in iron deficiency anemia: a narrative review and clinical implications.Annals of translational medicine · 2026Review
- Transferrin receptor 1-mediated iron uptake supports thermogenic activation in human cervical-derived adipocytes.FEBS letters · 2026Article
- Real-World Effectiveness of IHATNutrients · 2026Observational
- A Pilot Study of Salmon Protein Hydrolysate (ProGoBiomedicines · 2026Article
- Structure-Function Relationships in Polysaccharide-Iron Complexes: Molecular Characterization, Acid-Stress Release Stability, and Gastrointestinal Tolerability.Pharmaceutics · 2026Article
- Iron Metabolism in the Colorectal Tumor Microenvironment: Current Evidence and Clinical Implications.Diagnostics (Basel, Switzerland) · 2026Review
- A review - Prescribing iron salts: Comparison of efficacy and tolerance of different iron complexes.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2026Review
- Iron Oxide Nanoparticles Integrated in 3D-Printed Dosage Forms for Advanced Iron Supplementation.ACS nanoscience Au · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Iron-deficiency anemia and pre-anemic iron deficiency are the most frequent pathologies. The first line of treatment involves oral iron supplementation. The simplest, least expensive, and most commonly prescribed drug is ferrous sulfate, while other ferrous salts and ferric complexes with polysaccharides or succinylated milk proteins are also widely used. In recent years, novel iron formulations have been developed, such as the lipophilic iron donor ferric maltol, or nanoparticle encapsulated sucrosomial® iron. Oral iron supplementation is usually efficacious in correcting iron-deficiency anemia and replenishing iron stores but causes gastrointestinal side effects that reduce compliance. When oral iron supplementation is contraindicated, intravenous iron therapy can rapidly achieve therapeutic targets without gastrointestinal complications. Herein, we critically review literature on relative efficacy and tolerability of currently available oral iron supplements, and summarize recent data on optimal dosage and frequency.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.