Evidence map›Paper›PMID 38619804›Full record

ArticleNeurology and therapy2024

Vascular Endothelial Growth Factor and Ischemic Stroke Risk: A Mendelian Randomization Study.

Xiao Zhang, Xinzhi Hu, Shiyuan Fang, Jiayao Li, Zhichao Liu, Weidun Xie, Ran Xu, Adam A Dmytriw, Kun Yang, Yan Ma and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology and therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 4 countries.

Xiao Zhang *Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing, 100053, China.
Xinzhi Hu *Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, 100730, China.
Shiyuan Fang *Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, 100730, China.
Jiayao LiDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing, 100053, China.
Zhichao LiuSir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, UK.
Weidun XieDepartment of Computer Science, City University of Hong Kong, Kowloon, 999077, Hong Kong SAR.
Ran XuDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing, 100053, China.
Adam A DmytriwNeuroendovascular Program, Massachusetts General Hospital, Boston, MA, 02114, USA.
Kun YangDepartment of Neurosurgery, Tai'an Central Hospital, 29 Longtan Road, Tai'an, 271000, Shandong, China.
Yan MaDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing, 100053, China.
Liqun JiaoDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing, 100053, China. liqunjiao@sina.cn.
Tao WangDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing, 100053, China. wangtao_dr@sina.com.
Capital Medical University · CNPeking Union Medical College Hospital · CNUniversity of Oxford · GBCity University of Hong Kong · HKMassachusetts General Hospital · USTaian City Central Hospital · CN

Funding

Beijing Hospitals Authority's Ascent Plan DFL20220702Beijing Municipal Administration of Hospitals Incubating Program PX2021034Beijing Scientific and Technologic Project Z201100005520019National Natural Science Foundation of China 82171303National Natural Science Foundation of China 82301468
6 · The paper itself

Abstract

introductionPrevious studies have reported controversial relationships between circulating vascular endothelial growth factors (VEGF) and ischemic stroke (IS). This study aims to demonstrate the causal effect between VEGF and IS using Mendelian randomization (MR).

methodsSummary statistics data from two large-scale genome-wide association studies (GWAS) for 16,112 patients with measured VEGF levels and 40,585 patients with IS were downloaded from public databases and included in this study. A published calculator was adopted for MR power calculation. The primary outcome was any ischemic stroke, and the secondary outcomes were large-artery stroke, cardioembolic stroke, and small-vessel stroke. We used the inverse variance-weighted (IVW) method for primary analysis, supplemented by MR-Egger regression and the weighted median method.

resultsNine SNPs were included to represent serum VEGF levels. The IVW method revealed no strong causal association between VEGF and any ischemic stroke (odds ratio [OR] 1.01, 95% CI 0.99-1.04, p = 0.39), cardioembolic stroke (OR 1.04, 95% CI 0.97-1.12, p = 0.28), large-artery stroke (OR 1.02, 95% CI 0.95-1.09, p = 0.62), and small-vessel stroke (OR 0.98, 95% CI 0.91-1.04, p = 0.46). These findings remained robust in sensitivity analyses. MR-Egger regression suggested no horizontal pleiotropy.

conclusionsThis Mendelian randomization study found no relationship between genetically predisposed serum VEGF levels and risks of IS or its subtypes.

Indexed as

Causal associationCausal linkIschemic strokeMendelian randomizationStroke preventionVascular endothelial growth factor

Identifiers

PMID38619804
PMCPMC11136897
OpenAlexW4394819879

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.