Evidence map›Paper›PMID 38622996›Full record

ArticleACS nano2024

Polyester Nanoparticles with Controlled Topography for Peroral Drug Delivery Using Insulin as a Model Protein.

Ingrid Marie Heyns, Meenakshi Arora, Raghu Ganugula, Swetha Reddy Allamreddy, Shrusti Tiwari, Dhaval K Shah, Rita Basu, M N V Ravi Kumar

Abstract read
In one paragraph

Article in ACS nano, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ingrid Marie HeynsThe Center for Convergent Bioscience and Medicine (CCBM), The University of Alabama, Tuscaloosa, Alabama 35401, United States.ORCID 0000-0002-4323-892X
Meenakshi AroraThe Center for Convergent Bioscience and Medicine (CCBM), The University of Alabama, Tuscaloosa, Alabama 35401, United States.ORCID 0000-0003-3809-3153
Raghu GanugulaThe Center for Convergent Bioscience and Medicine (CCBM), The University of Alabama, Tuscaloosa, Alabama 35401, United States.ORCID 0000-0003-0262-5170
Swetha Reddy AllamreddyThe Center for Convergent Bioscience and Medicine (CCBM), The University of Alabama, Tuscaloosa, Alabama 35401, United States.ORCID 0009-0007-7958-262X
Shrusti TiwariDepartment of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, The State University of New York at Buffalo, 455 Pharmacy Building, Buffalo, New York 14214, United States.ORCID 0009-0009-1243-3018
Dhaval K ShahDepartment of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, The State University of New York at Buffalo, 455 Pharmacy Building, Buffalo, New York 14214, United States.ORCID 0000-0002-0723-6206
Rita BasuDivision of Endocrinology, Diabetes, and Metabolism, School of Medicine, Marnix E. Heersink School of Medicine, The University of Alabama, Birmingham, Alabama 35294, United States.
M N V Ravi KumarThe Center for Convergent Bioscience and Medicine (CCBM), The University of Alabama, Tuscaloosa, Alabama 35401, United States.ORCID 0000-0001-5606-401X

Funding

Proposal for Administrative supplement to Purchase NanoSight ProR01GM146097 · NIGMS · UNIVERSITY OF ALABAMA IN TUSCALOOSA · PI Ravikumar N Majeti, Dhaval K Shah · 2023 to 2026
$1.6M
Oral delivery of insulin using ligand-directed nanoparticles that do not compete with physiological ligandsR01DK125372 · NIDDK · UNIVERSITY OF ALABAMA IN TUSCALOOSA · PI GANUGULA, RAGHU, MAJETI, RAVIKUMAR N · 2020 to 2023
$1.5M
NIDDK NIH HHS R01 DK125372NIGMS NIH HHS R01 GM146097
6 · The paper itself

Abstract

Receptor-mediated polyester drug delivery systems have tremendous potential for improving the clinical performance of existing pharmaceutical drugs. Despite significant progress made in this area, it remains unclear how and to what extent the polyester nanoparticle surface topography would affect the

Indexed as

Drug Delivery SystemsInsulinNanoparticlesPolyestersAdministration, OralAnimalsDrug CarriersHumansMaleRatsRats, Sprague-DawleySurface PropertiesDrug CarriersInsulinPolyestersnanobiointerfacenanotopographyoral insulin deliverypolyester nanoparticlesreceptor-mediated transcytosis

Identifiers

PMID38622996
PMCPMC11145941

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.