Evidence map›Paper›PMID 38623306›Full record

ArticleOsteoarthritis and cartilage open2024

Laser-irradiating infrared attenuated total reflection spectroscopy of articular cartilage: Potential and challenges for diagnosing osteoarthritis.

P Krebs, M Nägele, P Fomina, V Virtanen, E Nippolainen, R Shaikh, I O Afara, J Töyräs, I Usenov, T Sakharova and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoarthritis and cartilage open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 4 countries.

P KrebsInstitute of Analytical and Bioanalytical Chemistry, Ulm University, Ulm, Germany.
M NägeleOptoPrecision GmbH, Bremen, Germany.
P FominaInstitute of Analytical and Bioanalytical Chemistry, Ulm University, Ulm, Germany.
V VirtanenResearch Unit of Health Sciences and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland.
E NippolainenDepartment of Technical Physics, University of Eastern Finland, Kuopio, Finland.
R ShaikhDepartment of Technical Physics, University of Eastern Finland, Kuopio, Finland.
I O AfaraDepartment of Technical Physics, University of Eastern Finland, Kuopio, Finland.
J TöyräsDepartment of Technical Physics, University of Eastern Finland, Kuopio, Finland.
I UsenovArt Photonics GmbH, Berlin, Germany.
T SakharovaArt Photonics GmbH, Berlin, Germany.
V ArtyushenkoArt Photonics GmbH, Berlin, Germany.
V TafintsevaFaculty of Science and Technology, Norwegian University of Life Sciences, Ås, Norway.
J H SolheimFaculty of Science and Technology, Norwegian University of Life Sciences, Ås, Norway.
B ZimmermannFaculty of Science and Technology, Norwegian University of Life Sciences, Ås, Norway.
A KohlerFaculty of Science and Technology, Norwegian University of Life Sciences, Ås, Norway.
O KönigNanoplus Advanced Photonics Gerbrunn GmbH, Gerbrunn, Germany.
S SaarakkalaResearch Unit of Health Sciences and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland.
B MizaikoffInstitute of Analytical and Bioanalytical Chemistry, Ulm University, Ulm, Germany.
Norwegian University of Life Sciences · NOUniversität Ulm · DEUniversity of Eastern Finland · FINanoplus (Germany) · DEOulu University Hospital · FIThe University of Queensland · AUUniversity of Oulu · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: A prototype infrared attenuated total reflection (IR-ATR) laser spectroscopic system designed for Methods: Results: Amide and carbohydrate signal behavior was observed to be almost identical between the obtained sparse IR data and previously measured FTIR data used for sparse partial least squares discriminant analysis (SPLSDA) to identify the spectral regions relevant to cartilage condition. Contact pressures between 0.3 and 0.4 ​MPa seem to provide the best sparse IR spectra for cylindrical (d ​= ​3 ​mm) probe tips. Conclusion: Laser-irradiating IR-ATR spectroscopy is a promising analytical technique for future arthroscopic applications to differentiate healthy and osteoarthritic cartilage tissue. However, this study also revealed that the flexible connection between the laser-based analyzer and the arthroscopic ATR-probe via IR-transparent fiberoptic cables may affect the robustness of the obtained IR data and requires further improvements.

Indexed as

ArthroscopyArticular cartilageInfrared spectroscopyOsteoarthritisQuantum cascade laser

Identifiers

PMID38623306
PMCPMC11016904
OpenAlexW4393951290

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.