ArticleJournal of dental research2024
Periodontitis, Dental Procedures, and Young-Onset Cryptogenic Stroke.
Article in Journal of dental research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- Machine Learning Stratification of Periodontal and Cerebrovascular Disease Status Using Salivary and Subgingival Lipopolysaccharide Activity.Journal of cellular and molecular medicine · 2026Article
- Preceding Infections and Coagulation Biomarkers in Early-Onset Cryptogenic Ischemic Stroke.Stroke · 2026Observational
- Modulation of LPS-associated virulence activity for reduction of periodontal inflammatory burden.Frontiers in microbiology · 2026Article
- Association of Subgingival Microbiota Composition With Risk, Severity, and Outcome of Cryptogenic Ischemic Stroke in Young Adults.Journal of the American Heart Association · 2025Observational
- Oral microbiome dysbiosis in cryptogenic ischemic stroke patients with high-risk patent foramen ovale.Scientific reports · 2025Article
- Association between regular dental scaling and stroke risk in patients with periodontal diseases: evidence from a Korean nationwide database.Epidemiology and health · 2025Article
- Oral Microbiome Dysbiosis as a Risk Factor for Stroke: A Comprehensive Review.Microorganisms · 2024Review
- Multikingdom oral microbiome interactions in early-onset cryptogenic ischemic stroke.ISME communications · 2024Article
- Shotgun metagenomic analysis of the oral microbiome in gingivitis: a nested case-control study.Journal of oral microbiology · 2024Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periodontitis is associated with an increased risk of ischemic stroke, and the risk may be particularly high among young people with unexplained stroke etiology. Thus, we investigated in a case-control study whether periodontitis or recent invasive dental treatments are associated with young-onset cryptogenic ischemic stroke (CIS). We enrolled participants from a multicenter case-control SECRETO study including adults aged 18 to 49 y presenting with an imaging-positive first-ever CIS and stroke-free age- and sex-matched controls. Thorough clinical and radiographic oral examination was performed. Furthermore, we measured serum lipopolysaccharide (LPS) and lipotechoic acid (LTA) levels. Multivariate conditional regression models were adjusted for stroke risk factors, regular dentist visits, and patent foramen ovale (PFO) status. We enrolled 146 case-control pairs (median age 41.9 y; 58.2% males). Periodontitis was diagnosed in 27.5% of CIS patients and 20.1% of controls (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.