Evidence map›Paper›PMID 38624088›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024

Peripheral HMGB1 is linked to O

Chandrama Ahmed, Hendrik J Greve, Carla Garza-Lombo, Jamie A Malley, James A Johnson, Adrian L Oblak, Michelle L Block

Open access · hybridAbstract read
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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  8. Progress in the mechanistic understanding of NETs formation in cancer.Medical oncology (Northwood, London, England) · 2025
    Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Peripheral HMGB1 is linked to OAlzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Chandrama AhmedDepartment of Pharmacology and Toxicology, Indiana University School of Medicine, The Stark Neurosciences Research Institute, Indianapolis, Indiana, USA.
Hendrik J GreveDepartment of Pharmacology and Toxicology, Indiana University School of Medicine, The Stark Neurosciences Research Institute, Indianapolis, Indiana, USA.
Carla Garza-LomboDepartment of Pharmacology and Toxicology, Indiana University School of Medicine, The Stark Neurosciences Research Institute, Indianapolis, Indiana, USA.
Jamie A MalleyDepartment of Pharmacology and Toxicology, Indiana University School of Medicine, The Stark Neurosciences Research Institute, Indianapolis, Indiana, USA.
James A JohnsonDepartment of Pharmacology and Toxicology, Indiana University School of Medicine, The Stark Neurosciences Research Institute, Indianapolis, Indiana, USA.
Adrian L OblakDepartment of Radiology and Imaging Sciences, Indiana University School of Medicine, The Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Michelle L BlockDepartment of Pharmacology and Toxicology, Indiana University School of Medicine, The Stark Neurosciences Research Institute, Indianapolis, Indiana, USA.ORCID 0000-0001-8303-7914
Indiana University School of Medicine

Funding

Indiana Medical Scientist/Engineer Training ProgramT32GM148382 · NIGMS · INDIANA UNIVERSITY INDIANAPOLIS · PI Benjamin Gaston, Emily K Sims · 2023 to 2026
$3.9M
The Role of Aspergillus versicolor and the Th2 Lung-Brain Axis in Alzheimer's Disease-like NeuropathologyR01AG076142 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI Adrian Lynn Oblak · 2022 to 2026
$3.3M
The Neuroimmune Hypothesis of Paraquat: Connecting the Periphery and BrainR01ES028104 · NIEHS · INDIANA UNIVERSITY INDIANAPOLIS · PI BLOCK, MICHELLE L · 2018 to 2022
$2.1M
HMGB1, Chlorpyrifos, and Persistent GWI-like NeuropathologyR01ES029835 · NIEHS · INDIANA UNIVERSITY INDIANAPOLIS · PI BLOCK, MICHELLE L · 2018 to 2022
$1.9M
The Role of Peripheral Immune Cell Trafficking in Ozone-Induced Alzheimer's Disease NeuropathologyRF1AG077826 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI OBLAK, ADRIAN LYNN · 2022 to 2022
$1.7M
O3 and the Lung-Brain Axis: Regulating Alzheimer's-like NeuropathologyI01BX004161 · VA · RLR VA MEDICAL CENTER · PI BLOCK, MICHELLE L · 2018 to 2021
–
BLRD VA I01 BX004161NIA NIH HHS R01 AG076142NIA NIH HHS RF1 AG077826NIEHS NIH HHS R01 ES028104NIEHS NIH HHS R01 ES029835NIH HHS 1RF1AG077826NIH HHS R01 ES028104NIH HHS RO1 ES029835GW
6 · The paper itself

Abstract

introductionOzone (O

methodsThe O

resultsO DISCUSSION: Astrocytes and peripheral myeloid cells are critical lung-brain axis interactors. HMGB1 loss in peripheral myeloid cells regulates the O HIGHLIGHTS: Astrocytes are part of the lung-brain axis, regulating how air pollution affects plaque pathology. Ozone (O

Indexed as

Alzheimer DiseaseAstrocytesHMGB1 ProteinOzoneAir PollutantsAmyloid beta-PeptidesAnimalsBrainDisease Models, AnimalLungMiceMice, TransgenicMicrogliaPlaque, AmyloidAir PollutantsAmyloid beta-PeptidesHMGB1 ProteinOzoneamyloid plaquesdisease‐associated astrocyteslung–brain axisO3peripheral HMGB1

Identifiers

PMID38624088
PMCPMC11095433
OpenAlexW4394835777

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.